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Application of fulvestrant in preparation of drugs for treating nonfunctional pituitary adenoma

A technique for fulvestrant, pituitary adenoma, applied in the fields of biochemistry and medicine

Active Publication Date: 2018-01-12
BEIJING NEUROSURGICAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is no less effective than tamoxifen in the treatment of patients with estrogen receptor positive breast cancer
There are no reports about fulvestrant in the treatment of adenoma

Method used

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  • Application of fulvestrant in preparation of drugs for treating nonfunctional pituitary adenoma
  • Application of fulvestrant in preparation of drugs for treating nonfunctional pituitary adenoma
  • Application of fulvestrant in preparation of drugs for treating nonfunctional pituitary adenoma

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Experimental program
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Effect test

Embodiment 1

[0023] 1.1 Specimen source

[0024] Specimens were obtained from surgically resected tumor tissues of patients with pituitary adenomas. Preoperative diagnosis was made based on clinical manifestations, serum hormone levels and imaging examinations, and then confirmed according to intraoperative findings, postoperative pathology and immunohistochemical staining. It was non-functioning pituitary adenoma: empty cell adenoma, macrophage Oncocytoma, gonadotroph adenoma, 30 cases of each non-functioning pituitary adenoma.

[0025] 1.2 Main reagents

[0026] Trypsin, DMEM medium, fetal bovine serum, dimethyl sulfoxide, and polylysine are all commercially available products.

[0027] 1.3 Cell culture

[0028] The surgically removed pituitary adenoma tissue is put into serum-free DMEM culture medium under aseptic operation, rinsed with sterile PBS in the ultra-clean bench for 2-3 times, removes connective tissue, necrotic tissue and blood clots, and cuts the specimen with ophthalmic...

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Abstract

The invention provides an application of fulvestrant in the preparation of drugs for treating nonfunctional pituitary adenoma. Through the abovementioned technical scheme, the prognosis of patients ofnonfunctional pituitary adenoma can be improved effectively.

Description

technical field [0001] The invention relates to the fields of biochemistry and medicine, in particular to the use of fulvestrant in the preparation of medicines for treating non-functional pituitary adenomas. Background technique [0002] Nonfunctional pituitary adenoma is the most common brain tumor among pituitary tumors. Although it is a benign tumor, it is very harmful and easy to relapse. It can damage the patient's vision, cause sudden blindness, and affect endocrine function. Infertility, severe cases can also lead to life-threatening. [0003] The treatment methods for pituitary adenoma mainly include drug therapy, surgical treatment, and radiotherapy. The current treatment is mainly based on surgery. A considerable number of patients have poor surgical results, and residual and recurrence often occur after surgery, which is a problem that is difficult to break through in neurosurgery. . Drug therapy is an effective way to solve this problem. However, there are st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/565A61P35/00
CPCA61K31/565A61P35/00
Inventor 高华李储忠张亚卓
Owner BEIJING NEUROSURGICAL INST