Pharmaceutical composition for treating proliferative diseases of hematopoietic system
A composition and drug technology, applied in the field of pharmaceutical preparations, can solve problems such as long hospital stay, increased complications, and increased treatment expenditure
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Embodiment 1
[0021] Cytarabine / Annamycin Nano Lipid Particle Injection
[0022] prescription:
[0023]
[0024] Preparation Process:
[0025] (1) Dissolve cytarabine in 150mL water for injection;
[0026] (2) Distearoylphosphatidylcholine, distearoylphosphatidylglycerol, cholesterol and Annamycin were dissolved in 300mL absolute ethanol;
[0027] (3) Remove absolute ethanol by rotary evaporating (2), add (1) and hydrate at 55°C for 1 hour to form crude lipid particles;
[0028] (4) pass the crude lipid particle through a high-pressure homogenizer at 1000 bar for 3 cycles, keep the temperature of the material below 30°C, and reduce the particle size to about 200nm;
[0029] (5) Ultrafiltration removes unencapsulated medicine;
[0030] (6) Dilute the nano-lipid particles to 1000mL
[0031] Fill 10mL / bottle into 10mL neutral borosilicate glass vials, stopper and cover to obtain cytarabine / Annamycin nano lipid particle injection.
Embodiment 2
[0033] Cytarabine / 4-desmethoxydaunorubicin hydrochloride nano lipid particle injection
[0034] prescription:
[0035]
[0036]
[0037] Preparation Process:
[0038] (1) Dissolve cytarabine in 150mL water for injection;
[0039] (2) Hydrogenated soybean phosphatidylcholine, methoxypolyethylene glycol-distearoylphosphatidylethanolamine and cholesterol are dissolved in 150mL absolute ethanol;
[0040] (3) After the two are mixed evenly, use an IKA high-speed shearing machine to mix at 10,000 rpm, add 450 mL of water for injection, and mix at 6,000 rpm;
[0041] (4) The above solution is transferred to a rotary evaporator, and the organic solvent is slowly evaporated to obtain the crude lipid particle;
[0042] (5) Pass the crude lipid particle through a high-pressure homogenizer at 1000 bar for 3 cycles, keep the temperature of the material below 30°C, and reduce the particle size to about 200nm;
[0043] (6) Ultrafiltration removes unencapsulated medicine, adjusts th...
Embodiment 3
[0047] Cytarabine / 4-desmethoxydaunorubicin Hydrochloride Nano Lipid Particles for Injection
[0048] prescription:
[0049]
[0050] Preparation Process:
[0051] (1) Dissolve cytarabine in 150mL water for injection;
[0052](2) Distearoylphosphatidylcholine, distearoylphosphatidylglycerol and cholesterol are dissolved in 150mL absolute ethanol;
[0053] (3) After the two are mixed evenly, mix evenly with an IKA high-speed shearing machine at 10000rpm, add 450mL of an aqueous solution containing sucrose in the prescribed amount, and mix evenly at 6000rpm;
[0054] (4) The above solution is transferred to a rotary evaporator, and the organic solvent is slowly evaporated to obtain the crude lipid particle;
[0055] (5) Pass the crude lipid particle through a high-pressure homogenizer at 1000 bar for 3 cycles, keep the temperature of the material below 30°C, and reduce the particle size to about 200nm;
[0056] (6) Ultrafiltration removes unencapsulated medicine, adjusts t...
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