Simultaneous multipoint excitation and matched receiving photoacoustic three-dimensional imaging device and method

Abstract

The invention discloses a simultaneous multipoint excitation and matched receiving photoacoustic three-dimensional imaging device and method, in the device, a computer processing system controls opening and closing of a photoacoustic signal excitation system, receives data processed by a photoacoustic signal preprocessing system, processes the data, performs reconstruction imaging, and controls athree-dimensional scanning system to run; the photoacoustic signal excitation system shapes pulse laser into a linear light source, and uses a micro lens array to focus a plurality of light focuses, and a sample is excited simultaneously by the plurality of light focuses to produce a multi-source photoacoustic signal; a photoacoustic signal receiving system receives the multi-source photoacousticsignal; the photoacoustic signal preprocessing system amplifies and filters the multi-source photoacoustic signal and sends the multi-source photoacoustic signal to the computer processing system; a to-be-imaged sample is put in a water tank, and the three-dimensional scanning system is used for regulating the spatial position of the water tank and the photoacoustic signal excitation system. Through use of the spatial layout of a microlens array and a linear acoustic detection array, rapid and wide range of photoacoustic three-dimensional imaging can be realized.

Description

technical field [0001] The invention relates to the field of photoacoustic imaging research, in particular to a photoacoustic three-dimensional imaging device and method for simultaneous multi-point excitation and matching reception. Background technique [0002] Photoacoustic imaging is a non-invasive imaging technology that combines optical imaging and ultrasound imaging. It has the characteristics of high contrast and high resolution of optical imaging and high penetration of ultrasound imaging. Photoacoustic imaging is based on the basic principle that light produces sound. When a short-pulse laser is irradiated on biological tissue, the biological tissue absorbs the pulse energy and expands rapidly to generate ultrasound, that is, the photoacoustic signal. According to the photoacoustic signal, the structure reflecting the biological tissue can be reconstructed. and images of feature information. Photoacoustic imaging overcomes the shortcomings of some traditional imag...

AI Technical Summary

Problems solved by technology

[0003] For photoacoustic imaging, it is of great significance to improve the imaging speed and realize real-time monitoring of dynamic physiological processes. However, limited by the repetition rate of pulsed laser and the speed of mechanical scanning, most of the current imaging modes with single optical focus and single acoustic focus are very difficult. Difficult to achieve high-speed photoacoustic 3D imaging

The patent application with application number 201010139117.X discloses a fast three-dimensional photoacoustic imaging system and method based on an area array ultrasonic detector. This invention establishes a non-scanning photoacoustic imaging system based on an area array detector to realize fast three-dimensional Photoacoustic imaging, but the disadvantage of this system is that the excitation light source is a non-focused laser, so the resolution of the system is determined by the acoustic resolution, but limited by the array element size and array element spacing of the area array ultrasonic detector, the system is difficult Achieving High-Resolution Photoacoustic Microscopy

The patent application with application number 201110171027.3 discloses a fast photoacoustic three-dimensional imaging device. This invention controls the on-off of each microlens in the optical mask through a programmable logic array module to avoid the use of a mechanical scanning device. Part of the micro-lens is disconnected, so that the utilization rate of the laser source is extremely low, and both the excitation of the light source and the acquisition of photoacoustic signals require complex circuit control, and the positions and timing of excitation and acquisition must be strictly unified. The entire hardware and program are very complicated. Not convenient for practical use

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