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Clarithromycin capsule composition

A technology of clarithromycin and a composition, applied in the field of clarithromycin capsule composition, can solve the problem of no prevention or treatment of liver cirrhosis, etc., and achieve the effects of reducing hydroxyproline content, good therapeutic effect, and reducing total lipid content

Inactive Publication Date: 2018-02-02
滁州先奇工业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the combined application of clarithromycin and tetrandrine in the prior art, especially there is no report on the prevention or treatment of liver cirrhosis after the combined application of the two

Method used

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  • Clarithromycin capsule composition
  • Clarithromycin capsule composition

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Embodiment 1

[0017] Embodiment 1: Take 100 g of clarithromycin, 20 g of tetrandrine, and 100 g of starch, pulverize them, mix them uniformly, prepare them with an appropriate amount of water as a binder, add an appropriate amount of lubricant talcum powder, and fill them into capsules.

Embodiment 2

[0018] Embodiment 2: Take 100 g of clarithromycin, 50 g of tetrandrine, and 100 g of dextrin, pulverize them, mix them uniformly, prepare them with an appropriate amount of water as an adhesive, add an appropriate amount of lubricant micronized silica gel, and fill them into capsules.

Embodiment 3

[0019] Embodiment 3: Take 100 g of clarithromycin, 30 g of tetrandrine, and 100 g of microcrystalline cellulose, pulverize them, mix them uniformly, prepare them with an appropriate amount of water as a binder, add an appropriate amount of lubricant talcum powder, and fill them into capsules.

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PUM

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Abstract

The invention belongs to the field of medicines, and discloses a clarithromycin capsule composition, which is prepared from the active ingredients, i.e., clarithromycin and tetrandrine, with the weight ratio being 1:(0.2 to 0.5). The clarithromycin and the tetrandrine are combined-applied, so that the hydroxyproline content and the total lipid content in a hepatic tissue can be remarkably reduced,and an anti-hepatic fibrosis function is realized.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a clarithromycin capsule composition. Background technique [0002] Clarithromycin is a derivative of erythromycin, successfully developed by Japan's Taisho Company in the early 1990s, and registered under the trade name Clarith. Thereafter, Taizheng first transferred its technology to Abbott of the United States for production. It was launched in Ireland and Italy in 1990, and was approved by the FDA in October 1991 as a Class IB new drug. The trade name was Biaxin. In 1993, it was launched in Hong Kong, China as Klacid. The trade name in Europe and Asia was called Klacid. It has been launched in many countries, and the market usage has grown steadily, and it has played an important role in clinical practice. Clarithromycin and its tablets, currently produced dosage forms also include granules, dispersible tablets, sustained-release tablets, injections and dry suspensions. ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/7048A61K31/4748A61P1/16
CPCA61K9/1652A61K31/4748A61K31/7048A61K2300/00
Inventor 孙本如赵菊兰
Owner 滁州先奇工业科技有限公司