Dry-period compound ceftiofur breast injectant composition, and preparation method thereof

Abstract

The invention relates to a dry-period compound ceftiofur breast injectant composition, and a preparation method thereof. The dry-period compound ceftiofur breast injectant composition comprises ceftiofur, berberine, a suspending agent, and a solid dispersion carrier, and is a white or off-white color ointment prepared via special technology. The preparation method is simple; the compound ingredients are stable; content release is stable; push injection is convenient to realize; and the matrix is soft. The dry-period compound ceftiofur breast injectant composition is an ointment, so that the dry-period compound ceftiofur breast injectant composition possesses a plurality of advantages compared with other injection compositions, the bioavailability is high, release is slow, effect lasts long, and sealing of nipple holes is realized after injection of the dry-period compound ceftiofur breast injectant composition into mammary chambers through milk vessels, so that retrograde intrusion ofbacteria into mammary chambers through nipple holes is prevented.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a formula of compound ceftiofur breast injection in the dry milk period and a preparation method thereof. Background technique [0002] According to the statistics of the International Dairy Cattle Federation, in the 1970s, the incidence rate of cow mastitis was 20%, and the prevalence rate of recessive mastitis was 50%. In several large cities in my country at the same period, the detection of dairy cows' milk showed that the detection rate of dairy cows' recessive mastitis was 20%-70%. In the 1980s, more than 60% of dairy cows in my country were infected with recessive mastitis, and 30%-50% of the udder area had recessive mastitis. In recent years, with the continuous development of intensive breeding industry, the level of antibiotic prevention and treatment has been further deepened. By implementing strict intramammary antibiotic prevention and teat di...

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Problems solved by technology

[0006] The dosage form of "a dry dairy cow udder perfusion agent for preventing and treating dairy cow mastitis and its preparation method (CN 1286463C; publication date: September 14, 2005)" is a perfusion agent, and polysorbate is required in the preparation process of the solution , water, etc., there are disadvantages such as easy destruction of active ingredients after demulsification, high requirements for transportation and storage conditions, and lack of protection for cow teats

[0007] "Preparation Process of Compound Ceftiofur Oil Suspension Injection (101406447A; Publication Date: 2009-04-15)", the preparation form of this patent is a suspension, and the raw materials are easy to settle after being injected into the udder of a cow, and it is easy to form a local main drug content Too high, easy to form part of the tissue toxic accumulation in the breast

[0008] "A long-acting ceftiofur hydrochloride injection and its preparation method (101874773A; publication date: 2010-11-03)", this patent is a unilateral long-acting injection, for bacteria resistant to ceftiofur alone, this kind The clinical effect of injection is worrying

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