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Nanoscale compound antibacterial agent and preparation method and application thereof

A nano-composite, antibacterial agent technology, applied in the field of antibacterial agents, can solve the problems of nano-silver antibacterial agents that are not stable enough, and the antibacterial efficacy needs to be further improved, and achieve the effect of green environmental protection, fast speed and simple operation in the production process

Active Publication Date: 2018-03-23
贵州瑞诚新材料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nano-silver antibacterial agent formed by the combination of nano-silver and carrier is generally not stable enough, and the antibacterial effect of antibacterial material using nano-silver alone needs to be further improved.

Method used

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  • Nanoscale compound antibacterial agent and preparation method and application thereof
  • Nanoscale compound antibacterial agent and preparation method and application thereof
  • Nanoscale compound antibacterial agent and preparation method and application thereof

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Embodiment approach

[0069] In order to further improve the antibacterial ability of the nanocomposite antibacterial agent, as a preferred embodiment of the present invention, the nanocomposite antibacterial agent also includes titanium dioxide with a mass fraction of 0.01-10%;

[0070] And / or, the nanocomposite antibacterial agent further includes zinc oxide with a mass fraction of 0.01-10%.

[0071] Both titanium dioxide and zinc oxide have a certain antibacterial ability, and they are added to the nano-composite antibacterial agent to cooperate with nano-silver and graphene to form an antibacterial agent with stronger antibacterial ability.

[0072] Typical but non-limiting mass fractions of titanium dioxide are 0.01%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10%. Typical but non-limiting mass digits of zinc oxide are 0.01%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% .

[0073] The nanocomposite antibacterial agent provided by the invention can self-identify, adsorb, shiel...

Embodiment 1

[0095] A kind of nanocomposite antibacterial agent provided by the present embodiment is made of the following raw materials in mass fraction: evening primrose oil 1%, nano silver 0.01%, graphene 0.1%, protein 0.1%, phospholipid 1%, chitosan 0.2% %, cholesterol 2%, vitamin E 0.2%, ethanol 2%, monoglyceride 0.5%, dibutyl hydroxytoluene 0.2%, alkyl glucoside 1%, and water to make up the balance to 100%.

Embodiment 2

[0097] A kind of nanocomposite antibacterial agent provided by the present embodiment is made of the following raw materials in mass fraction: grape seed oil 11%, nano silver 0.05%, graphene 1%, protein 0.3%, phospholipid 3%, chitosan 0.3% , cholesterol 1%, vitamin C 0.5%, vitamin E 0.5%, propylene glycol 4%, glyceryl stearate / PEG-100 stearate 1%, tert-butyl hydroquinone 0.4%, alkyl glucoside 0.8%, sodium cocoyl isethionate 0.2%, xanthan gum 0.5%, polyethylene glycol 0.3%, silicon dioxide 0.2%, water to make up the balance to 100%.

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Abstract

The invention provides a nanoscale compound antibacterial agent and a preparation method and application thereof, which relate to the technical field of antibacterial agents. The nanoscale compound antibacterial agent is mainly prepared from nanosilver, graphene, protein, phospholipid, polysaccharide, cholesterol, vitamin and other raw materials, functional substances, such as the vitamin, are wrapped by a lipidosome formed by the protein, the phospholipid, the cholesterol and other materials, moreover, the nanosilver, the graphene and other materials are loaded inside or on the surface of thelipidosome after being compounded, and thereby the nanoscale compound antibacterial agent which is highly similar to a cellular structure is produced. The speed by which the compound antibacterial agent gets into microbial cells is high, and the compound antibacterial agent can gather around a focus to generate a high-concentration drug effect; because the surface of the compound antibacterial agent is positively charged, the compound antibacterial agent can selectively adsorb, wrap, shield and kill pathogenic bacteria and viruses, the surfaces of pathogenic bacteria and viruses which are negatively charged, thus having a high antibacterial effect. The invention further provides the preparation method of the nanoscale compound antibacterial agent, and the method can realize the uniform mixing of all the materials, thus being favorable for the increase of the stability of the nanoscale compound antibacterial agent.

Description

technical field [0001] The invention relates to the technical field of antibacterial agents, in particular to a nanocomposite antibacterial agent and its preparation method and application. Background technique [0002] With the improvement of people's living standards and health awareness in our country, the demand for antibacterial agents has greatly increased, and various antibacterial agents have been continuously developed and applied. Antibacterial agents mainly include inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents. Although both organic antibacterial agents and natural antibacterial agents have certain antibacterial capabilities, they have different problems. Organic antibacterial agents have poor heat resistance, are easy to hydrolyze, have a short service life, and have low antibacterial efficacy. They may cause damage to normal cells while killing pathogenic bacteria and viruses. However, natural antibacterial agent...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K47/04A61K47/42A61P31/00A61P33/00A61P15/02A61K8/19A61K8/67A61Q19/00A61Q17/00A23L3/358A61P17/02A61P17/10A61P17/00A01N59/16A01N27/00A01N25/00A01N25/04A01N25/22A01P1/00A01P3/00A61K31/05A61K31/07A61K31/51A61K31/375A61K31/59A61K31/355A61K31/525A61K31/4415A61K31/714
CPCA01N25/00A01N25/04A01N25/22A01N27/00A01N59/16A23L3/358A61K8/19A61K8/67A61K8/671A61K8/673A61K8/676A61K8/678A61K31/05A61K31/07A61K31/355A61K31/375A61K31/4415A61K31/51A61K31/525A61K31/59A61K31/714A61K33/38A61K47/02A61K47/42A61K2800/10A61K2800/592A61Q17/005A61Q19/00A61K2300/00
Inventor 韦勇
Owner 贵州瑞诚新材料技术有限公司
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