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Apparatus and methods for measuring electrical current

A technology of equipment and current, applied in the direction of measuring current/voltage, measuring electrical variables, measuring devices, etc., to achieve the effect of eliminating influence

Active Publication Date: 2018-03-27
OXFORD NANOPORE TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practice, however, other noise sources exist, and low-pass filtering and correlated double sampling are not always sufficient to achieve the desired noise performance

Method used

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  • Apparatus and methods for measuring electrical current
  • Apparatus and methods for measuring electrical current
  • Apparatus and methods for measuring electrical current

Examples

Experimental program
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Embodiment Construction

[0038] In an embodiment, a device 50 for measuring the current output by the sensor element 56 is provided. exist Figure 7 The example configuration of the device is shown in . In an embodiment, the sensor element 56 is configured to sense the occurrence of a physical event or phenomenon by outputting an electrical signal in the form of an electrical current. The physical event or phenomenon may be an interaction between a molecular entity and the sensor element 56, such as an interaction between a molecular entity and a membrane protein such as a protein pore.

[0039] Device 50 includes current sensing circuitry 52 and readout circuitry 54 configured to perform various operations at particular relative timings. exist Image 6 with 8 Example timing is illustrated in the graph of , where the horizontal axis represents time and the vertical axis represents the presence or absence of pulses representing specific functionality. The pulses shown correspond respectively to a ...

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Abstract

Arrangements are disclosed for measuring small electrical currents with high sensitivity, for example in the context of sensing molecular entities, for example via interactions between the molecular entities and a membrane protein inserted in an amphiphilic membrane. In one arrangement there is provided a current sensing circuit (52) configured to integrate the current output by a sensor element (56) during each of a plurality of sensing frames (62). In each sensing frame (62) first and second analogue samples of the integral are taken during first and second time windows (71,72). A readout circuit (54) processes the first and second analogue samples to output a digital output signal representing the current output by the sensor element (56). The processing comprises analogue to digital conversion processing and output processing. The output processing is performed exclusively during periods outside of the first and second time windows.

Description

technical field [0001] The present invention relates to measuring small currents with high sensitivity in the context of molecular entities, for example by sensing the interaction between said molecular entities and sensors comprising membrane proteins intercalated in amphiphilic membranes, especially but not exclusively. Background technique [0002] The use of membrane proteins inserted in amphiphilic membranes is known to sense molecular entities. Interactions between molecular entities and membrane proteins can result in characteristic modulations of electrical signals that emerge across amphiphilic membranes. For example, the ionic current flowing through a membrane protein that is a protein pore can be modulated by crosstalk. By monitoring the electrical signals emerging across the amphiphilic membrane, it is possible to detect property modulations and thereby sense molecular entities. Various techniques have been proposed based on this principle, one example is disc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R19/00
CPCG01R19/0053G01N33/48721G01N33/48728
Inventor 大卫·A·菲什史蒂文·保罗·怀特
Owner OXFORD NANOPORE TECH LTD