Compositions and methods for reducing visual loss

A composition and drug technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc.

Inactive Publication Date: 2018-04-17
EDGE THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, it raises the question whether there is a specific time of day to administer antihypertensive drugs for optimal therapeutic outcome (Jonas JB et al., Am.J.Ophthalmol.142(1), 144-145(2006))
[0063] Despite Availability of Therapeutics, One of the Biggest Barriers to Controlling Glaucoma Is Adherence

Method used

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  • Compositions and methods for reducing visual loss
  • Compositions and methods for reducing visual loss
  • Compositions and methods for reducing visual loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0449] Embodiment 1. The effect of nimodipine preparation on glaucoma patients

[0450] A test formulation containing a microparticulate nimodipine formulation with a uniform particle size distribution will be prepared by combining a polymer solution (eg, a 50-50 glycolide-lactide blend) with a solvent in the presence of nimodipine. The mixture is added to a surfactant-containing aqueous solution to form an emulsion, and the solvent is extracted to produce a flowable microparticle nimodipine formulation. The initial drug loading will be 65%, ie, 65% nimodipine and 35% polymer. The average particle size will be about 52 μm.

[0451] Microparticulate nimodipine formulations can be combined with additional therapeutic agents (eg, prostaglandin analogs, Rho kinase inhibitors) and pharmaceutical carriers to form pharmaceutical compositions of the described invention. A vehicle such as saline (hydroxypropylmethylcellulose (HPMC) in phosphate buffered saline (PBS)) can be mixed wit...

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Abstract

The described invention provides a method for reducing visual loss and for treating one or more of adverse consequence of an eye disease, including abnormal intraocular pressure, retinal vascular disease, retinal ganglion cell death, or a combination thereof in order to reduce visual loss. The method entails providing a flowable particulate composition that contains a particulate formulation comprising a plurality of particles of uniform size distribution, a therapeutic amount of a therapeutic agent selected from a voltage-gated calcium channel antagonist, an endothelin receptor antagonist, ora combination thereof, and optionally an additional therapeutic agent, wherein the particles are of uniform size distribution, and wherein each particle comprises a matrix; and a pharmaceutically acceptable carrier.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Application No. 62 / 168,588, filed May 29, 2015, which is hereby incorporated by reference in its entirety. technical field [0003] The described invention relates to compositions, systems, and methods for reducing vision loss and for treating one or more adverse consequences of eye disease, including abnormal intraocular pressure, retinal vascular disease, and retinal ganglion cell death, in order to reduce vision loss method. Background of the invention [0004] glaucoma [0005] Glaucoma, a retinal vascular disease, is the most common optic neuropathy, the second most common cause of blindness, and the most common cause of preventable visual disability worldwide (Chua B. and Goldberg I, Expert Rev Ophthalmol 2010; 5(5 ); 627-36). It encompasses a spectrum of progressive optic neuropathies characterized by pathological degeneration of unmyelinated r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K9/08A61P27/06
CPCA61K9/1647A61K31/4422A61K31/5575A61K45/06A61K9/0048A61K9/0051A61P27/02A61P27/06A61P27/10A61P43/00A61K2300/00A61K9/08
Inventor R.L.麦克唐纳
Owner EDGE THERAPEUTICS
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