A kind of muscone patch and its preparation method and application

A musk ketone patch and musk ketone technology are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and sheet delivery, etc., which can solve the problems of lack of ischemic stroke, and achieve the reduction of MDA content and cerebral infarction index. , Improve the effect of SOD vitality

Active Publication Date: 2021-02-02
山东宏济堂制药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the lack of suitable preparations for the treatment of ischemic stroke at present, the present invention needs to develop a new dosage form to overcome the defects of oral administration and injection preparations, avoid liver first-pass effect and gastrointestinal inactivation, and maintain a constant blood concentration to enhance the therapeutic effect , reduce toxic side effects

Method used

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  • A kind of muscone patch and its preparation method and application
  • A kind of muscone patch and its preparation method and application
  • A kind of muscone patch and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 52.5mg of muscone and 25.0g of silicone pressure-sensitive adhesive to 3mL of ethyl acetate to dissolve, mix evenly, and stir for 0.5h in an airtight manner. 2 On the backing layer of polyethylene terephthalate, form the adhesive layer containing medicine, after drying, press and cover the anti-adhesive layer (200cm 2 ), punching and cutting to obtain 200 drug-loaded patches.

Embodiment 2

[0023] Add 105.0mg of muscone and 25.0g of silicone pressure-sensitive adhesive to 3mL of ethyl acetate to dissolve and mix evenly. Stir in an airtight chamber for 1 hour, degas under reduced pressure, and spread on 200cm 2 On the backing layer of polyethylene terephthalate, form the adhesive layer containing medicine, after drying, press and cover the anti-adhesive layer (200cm 2 ), punching and cutting to obtain 200 drug-loaded patches.

Embodiment 3

[0025] The drug effect animal experiment result of the prepared muscone patch of the present invention is as follows:

[0026] Dosing regimen:

[0027] Get 70 Wistar rats, randomly divide into sham operation group, model group, muscone patch high dose group (MHD) (4.20mg / kg), muscone patch medium dose group (MMD) (2.10mg / kg) , muscone patch low dose group (MLD) (1.05mg / kg), nimodipine group (ND) (4mg / kg) and Yinkeluo group (YKL) (40mg / kg), 10 animals in each group. The sham operation group and the model group were intragastrically administered with normal saline and pasted with a blank patch on the front side of the neck (common carotid artery) of the rats after hair removal; Paste on the neck of rats after hair removal; Nimodipine group and Yinkeluo group were given corresponding doses of nimodipine and Yinkeluo respectively, and a blank patch was pasted on the neck of rats after hair removal, every day 1 time, 7 days in a row.

[0028] Experiment 1: Protective effect of m...

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Abstract

The invention discloses a muscone patch, its preparation method and application. It includes a backing layer and an anti-adhesive layer, and the adhesive layer containing medicine is between the backing layer and the anti-adhesive layer, and the adhesive layer containing medicine includes muskone and skeleton material. The skeleton material is silicone pressure-sensitive adhesive, the backing layer is polyethylene terephthalate, and the anti-adhesive layer is smooth thick paper treated with paraffin. The invention makes the muskone into a patch, which overcomes the defects of oral administration and injection preparations, avoids liver first-pass effect and gastrointestinal inactivation, maintains a constant blood drug concentration, enhances therapeutic effect, and reduces toxic and side effects. The use of the patch can also reduce the frequency of medication, and is suitable for the treatment of ischemic stroke, especially in the recovery period of stroke.

Description

technical field [0001] The invention relates to the technical field of muskone medicine and its application, in particular to a muskone patch and its preparation method and application. Background technique [0002] Stroke has always been a serious disease that threatens human health, and ischemic stroke is the main type of stroke. Ischemic stroke is also called ischemic cerebrovascular disease. The key to its treatment is anti-cerebral edema, improvement of cerebral blood circulation and brain protection, so as to restore the blood supply of the ischemic area and save dying neurons. The treatment methods mainly include reducing intracranial pressure, regulating blood pressure, anticoagulation, thrombolysis, protecting microcirculation and brain protection. [0003] The traditional dosage forms for the treatment of ischemic stroke are mainly decoctions, capsules, oral liquids, tablets, and injections. However, these dosage forms have the disadvantages of large amount of us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/122A61P9/10
CPCA61K9/703A61K31/122
Inventor 魏永恒谭乐俊李利芬崔曰新战旗李樱孟兆青
Owner 山东宏济堂制药集团股份有限公司
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