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Application of trichloro-substituted type ii halogenated polyketides

A polyketone compound, chlorine substitution technology, applied in the field of microorganisms, can solve the problems of low yield and small output

Active Publication Date: 2020-02-11
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, due to the defect of the preparation method, the yield obtained is relatively small, and the yield is also low. At the same time, because the yield is very small (about 7 mg for each compound), only the drug-resistant Staphylococcus aureus activity has been done. In order to further obtain other antibacterial activity, the applicant conducted research on the preparation method, and finally obtained the preparation method with high biomass, and conducted research on other antibacterial activities

Method used

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  • Application of trichloro-substituted type ii halogenated polyketides
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  • Application of trichloro-substituted type ii halogenated polyketides

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Embodiment Construction

[0032] The present invention is described in further detail below by specific embodiments:

[0033] 1. Activation of Streptomyces sp. FJS31-2 strain

[0034] Take out the strains stored on the glycerol slant from the -80°C refrigerator, dig out the spores of one ring of strain Streptomyces sp. FJS31-2 with a sterile inoculating loop, inoculate the basal medium plate with a diameter of 11cm with a cross streak, and let stand at 28°C After culturing for 3 days, pick a single colony and pass it to the third generation to expand the culture.

[0035] 2. Fermentation culture of fermentation products

[0036] Streptomyces sp.FJS31-2 bacterial strain selects improved GYD solid medium for fermentation and culture, packs 150mL fermentation medium in a specification 500 mL conical flask, and adds agar powder to 1.8% of the agar powder quality and fermentation medium volume in each bottle. The inoculation amount of each bottle is the amount of activated bacteria on the culture plate wi...

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Abstract

The invention discloses an application of a trichlorine substituted II-type halogenated poly-ketone compound, which has the structural formula represented as follow. The compound has anti-Gram-positive bacteria, anti-Gram-negative bacteria or anti-fungus activities. Through modification of the preparation method, more trichlorine compounds can be produced. In addition, antibacterial functions of the modified compounds are screened; the results prove that the compound has wide-spectral antibacterial activities, and has the anti-Gram-positive bacteria activity, such as methicillin-resistant Staphylococcus aureus (MRSA) and drug-resistant bacteria thereof, staphylococcus epidermidis and bacillus subtilis, and the anti-Gram-negative bacteria activity, such as escherichia coli generating extended spectrum beta-lactamases (ESBL), proteusbacillus vulgaris and bacterium burger, and anti-fungus activity, such as candida albicans.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to the application of a trichloro-substituted type II halogenated polyketone compound, in particular to the application of a trichloro-substituted halogenated type II polyketone compound zunyimycin C. Background technique [0002] Natural products derived from Streptomyces often have good biological activity and drug potential, and are an important source of antibiotics. However, with the abuse of antibiotics, the emergence of many "super bacteria" has brought huge challenges to the clinical treatment of pathogenic bacterial infections and other diseases, and some super bacteria have appeared incurable phenomenon. In view of the current increasingly severe antibacterial situation, it is imperative to intensify the research and development of antibiotics and explore and develop new antibiotics, which is also an effective way to solve the problem of antibiotic resistance. [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/357A61P31/04A61P31/10
CPCA61K31/357Y02A50/30
Inventor 钱声艳刘建国宋长伟王方远杨彩玲王倩
Owner ZUNYI MEDICAL UNIVERSITY
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