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Preparation method of 1-methyl-2-ethylimidazole

A technology of ethyl imidazole and methyl group, applied in the field of preparation of 1-methyl-2-ethyl imidazole, can solve the problems of unfavorable environment protection, low product yield, many wastes, etc. protective effect

Inactive Publication Date: 2018-05-01
JIANGXI JINKAI CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Based on this, the purpose of the present invention is in order to solve the existing process of synthesizing 1-methyl-2-ethylimidazole, product yield is lower, and can produce more three waste bodies, the problem that is unfavorable for the protection of environment

Method used

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  • Preparation method of 1-methyl-2-ethylimidazole
  • Preparation method of 1-methyl-2-ethylimidazole
  • Preparation method of 1-methyl-2-ethylimidazole

Examples

Experimental program
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Effect test

Embodiment 1

[0024] see figure 1 , for the preparation method of 1-methyl-2-ethylimidazole proposed in the first embodiment of the present invention, wherein the method comprises the following steps:

[0025] (1) After adding 2-ethylimidazole into a reaction kettle, slowly add the acid-binding agent, and continue to add the aprotic solvent under the condition of stirring.

[0026] Wherein, the above-mentioned acid-binding agent can be sodium hydroxide or potassium hydroxide. After adding the acid-binding agent, the mixed solution in the reactor is stirred, and then continue to add the aprotic solvent. In the present invention, the aprotic solvent can be any one of tetrahydrofuran, acetonitrile or dimethyl sulfoxide.

[0027] (2) Feed methyl chloride into the mixed solution in the reaction kettle, after fully reacting for the first preset time at a preset temperature, filter the mixed solution obtained after the reaction, and remove the filtrate under normal pressure conditions The said ...

Embodiment 2

[0032] Below, we will describe in more detail the preparation method of 1-ethyl-2-methylimidazole with a specific experimental process:

[0033] Please refer to Table 1:

[0034] Table one, the impact of different reaction temperatures on the yield of product 1-ethyl-2-methylimidazole

[0035] temperature

40℃

50℃

60℃

65℃

70℃

yield

no response

65.16％

70.25％

76.19％

/

[0036] As can be seen from Table 1: when the reaction temperature is 65°C, the yield of the corresponding product 1-ethyl-2-methylimidazole is the highest, so in this embodiment, the optimum reaction temperature of the reaction is is 65°C.

[0037] Please refer to Table 2:

[0038] Table two, the impact of different molar ratios of reaction raw materials on the yield of product 1-ethyl-2-methylimidazole

[0039]

[0040]

[0041] As can be seen from Table 2, when the molar ratio of 2-ethylimidazole and methyl chloride was 1:1.2, the yield of correspondi...

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Abstract

The invention relates to a preparation method of 1-methyl-2-ethylimidazole. The method comprises the following steps: after 2-ethylimidazole is added into a reaction kettle, an acid-binding agent is slowly added, and an aprotic solvent is continuously added under the condition of stirring; chloromethane is injected into the mixed solution in the reaction kettle; after a first preset time of sufficient reaction under preset temperature, the mixed solution obtained after reaction is filtered, the aprotic solvent in filtrate is removed under the condition of atmospheric pressure, and reduced pressure distillation is performed, so that the 1-methyl-2-ethylimidazole is obtained. The preparation method of the 1-methyl-2-ethylimidazole, disclosed by the invention, does not produce three types ofwastes in the process of preparation, and therefore is good for environment protection, and the requirement of application in actual production is met.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 1-methyl-2-ethylimidazole. Background technique [0002] Among a wide variety of chemicals, imidazole is a relatively important compound. Imidazole is weakly alkaline and toxic. During the production process, the production equipment generally needs to be sealed. Imidazoles are generally stored in a cool, ventilated and dry place, and attention should be paid to protection from heat, moisture, sun and collision. [0003] Specifically, imidazole is a five-membered aromatic heterocyclic compound containing two meta-nitrogen atoms in the molecular structure. The unshared electron pair of the 1-position nitrogen atom in the imidazole ring participates in ring conjugation, and the electron density of the nitrogen atom decreases. Make the hydrogen on this nitrogen atom easy to leave in the form of hydrogen ions. Its structure determines that it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/58
CPCC07D233/58
Inventor 胡健火李平
Owner JIANGXI JINKAI CHEM CO LTD