System and method for irreversible electroporation with thermally controlled electrodes

A technology of irreversible electricity and electrodes, applied in electrotherapy, heating surgical instruments, parts of surgical instruments, etc., can solve problems such as increasing arc discharge

Active Publication Date: 2018-05-11
安吉戴尼克公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Additionally, thermal issues can increase the likelihood of arcing when desired process parameters are applied

Method used

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  • System and method for irreversible electroporation with thermally controlled electrodes
  • System and method for irreversible electroporation with thermally controlled electrodes
  • System and method for irreversible electroporation with thermally controlled electrodes

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[0055] The present invention can be understood more readily by reference to the following detailed description and examples contained therein, as well as to the accompanying drawings and descriptions before and after. The drawings, which are not necessarily to scale, depict selected preferred embodiments and are not intended to limit the scope of the invention. The detailed description illustrates the principles of the invention by way of example and not limitation.

[0056] Those skilled in the art will readily appreciate that the devices and methods described herein are exemplary only and that changes may be made without departing from the spirit and scope of the invention. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not limiting.

[0057] As used herein, the term "proximal" refers to a direction closer to the operator and the term "distal" refers to a direction closer to (insertion) the pa...

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Abstract

A treatment device and method for delivering electrical pulses capable of creating irreversible electroporation. The system may include a bipolar probe with open or closed perfusion with the purpose of controlling the electrical conductivity rise to eliminate electrical arcing without significantly altering the electric field distribution and treatment zone. This invention may include perfusion together with the delivery of specific or customized pulse parameters to achieve clinically acceptable ablation sizes using a bipolar probe with while reducing the overall risk of arcing or system failure.

Description

[0001] Cross References to Related Applications [0002] This application incorporates by reference U.S. Provisional Patent Application 62 / 145,581, filed April 10, 2015, U.S. Provisional Patent Application 62 / 151,513, filed April 23, 2015, The entire disclosure of US Provisional Patent Application 62,173 / 538 and US Nonprovisional Patent Application 12 / 437,843, filed May 8, 2009, entitled "Electroporation Device and Method of Use." Background technique [0003] Irreversible electroporation (IRE) and other electroporation-based therapies (EBT), such as electrochemotherapy and electrogene therapy, use the delivery of brief but intense electrical pulses delivered through multiple electrodes into the tissue to treat the intended treatment of the tissue area. These electrical pulses subject cells in tissues to electric fields, which alter their intrinsic transmembrane potential and, at sufficient intensity, lead to the creation of nanoscale defects that facilitate macromolecular t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61B18/00A61B18/04A61B18/12A61B18/14A61M25/00
CPCA61M25/00A61B2018/00011A61B2018/00023A61B2018/00029A61B2018/00613A61B2018/00744A61B2018/00791A61B2018/00827A61B18/1477A61B17/00A61B2017/00097A61N1/327
Inventor R·尼尔S·N·戈登博格G·辛格尔
Owner 安吉戴尼克公司
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