Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Transpapillary methods and compositions for treating breast disorders

A composition, nipple technology, applied in the directions of drug combination, drug delivery, medical formula, etc., can solve problems such as side effects

Inactive Publication Date: 2018-05-11
ATOSSA THERAPEUTICS INC
View PDF19 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Adjuvant therapy such as oral delivery of tamoxifen is known to have serious side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] Example 1. Endoxifene Permeation of Skin Model

[0170] This example describes an in vitro skin model used to study endoxifene penetration.

[0171] pig skin model

[0172] Strips of post mortem sow udders were obtained from a local abattoir and shipped to the laboratory in frozen HEPES modified Hanks buffered balanced salt solution (HBBS). Freshly excised porcine udder teat strips were washed in warm water and the udder teat surrounded by 2 cm x 2 cm of abdominal skin was excised by blunt dissection. Cutaneous adipose tissue was also removed by blunt dissection and the fragments were maintained in HHBS until prepared in a diffusion cell.

[0173] In vitro transmammary delivery was tested using a Franz diffusion cell system consisting of 2 separate chambers (donor and recipient). Pig udder samples were fixed between pool compartments whose flanges were coated with high-vacuum silicone grease, with the udder teat centered and facing upwards, as described by Lee et al....

Embodiment 2

[0178] Example 2. Transmapplemental Delivery of Endoxifene Gel

[0179]Individuals diagnosed with hyperplasia in two mammary ducts (one duct in their right breast and one duct in their left breast) were treated with endoxifen delivered by the transmapple method as follows. In the following non-limiting examples, the individual was diagnosed with hyperplasia using nipple aspirate (NAP). Alternatively, another diagnostic method, such as mammography, may be used. Removes keratin blockages in breast ducts. A sufficient amount of NAP was collected from each breast of the subject. Samples from each breast were analyzed using cytology tests and antibodies against the cancer biomarkers CK5, CK14, CK7, CK18, and p53 were used to determine the expression patterns of these biomarkers. Analysis revealed ductal proliferative disorders in two suspected ducts.

[0180] Each nipple containing a suspected duct in this individual was swabbed with ethanol and allowed to air dry prior to trea...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

Methods and treatments are taught for the treatment of breast disorders, including proliferative breast disease, breast cancer, and increased breast density. The methods and compositions deliver efficacious formulations of chemical and / or biological treatment medicaments to the breast via a transpapillary route.

Description

[0001] cross reference [0002] This application claims priority to US Provisional Patent Application No. 62 / 192,505, filed July 14, 2015, which is hereby incorporated by reference in its entirety. Background technique [0003] Breast cancer is by far the most common form of cancer in women and the second leading cause of cancer death in humans. Despite advances in breast cancer diagnosis and treatment, the incidence of the disease has increased steadily at a rate of about 1% per year since 1940. Today, a woman living in North America is one in eight likely to develop breast cancer during her lifetime. [0004] Breast disorders include breast cancer and benign but often precancerous lesions such as ductal hyperplasia, lobular hyperplasia, atypical ductal hyperplasia and atypical lobular hyperplasia. Breast cancer includes any malignant tumor of cells in the breast. There are several types of breast cancer. Exemplary breast cancers include, but are not limited to, ductal c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/138A61P35/00
CPCA61K31/357A61K31/405A61K31/138A61P35/00A61K31/202A61K31/592A61K31/593A61K45/06A61K2300/00A61K9/0041
Inventor 史蒂文·C·夸伊
Owner ATOSSA THERAPEUTICS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com