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Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition

An extract and echinacea technology are used in the preparation of antiviral compositions. Echinacea and Salvia miltiorrhiza extracts are used in the field of preparation of antiviral compositions, which can solve the problem of severe burden in children, worry about complications, and lack of enterovirus71 type and human adenovirus-specific antiviral drugs, etc., to reduce drug resistance and inhibit adenovirus and enterovirus infections

Active Publication Date: 2018-05-22
张銮英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, adenovirus infection leads to severe disease burden and worrisome complications in children
[0004] Currently there is a lack of specific antiviral drugs for the treatment of enterovirus 71 and human adenovirus

Method used

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  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Preparation of Plant Extracts and Analysis of Index Components

[0066] 1.1 Preparation method

[0067] This example illustrates the preparation method of the plant extract used in the preparation of the antiviral composition of the present invention. Echinacea extract and Danshen extract use water or a mixture of alcohol and water as the extraction solvent. The so-called alcohol-water mixture herein refers to the mixture of various alcohols and water, such as methanol aqueous solution, ethanol aqueous solution, 2-propanol aqueous solution, wherein, the volume ratio (v / v) of the alcohols relative to the alcohol-water mixture can be 1~95%. The extracts of different plants have similar preparation methods. The water extract of Echinacea and the 70% ethanol extract of Salvia miltiorrhiza are taken as examples below to illustrate the preparation steps of the water extracts or alcohol extracts of these two plants.

[0068] In order to prepare the water extract of Echinace...

Embodiment 2

[0084] Antiviral activity of echinacea extract and salvia miltiorrhiza extract

[0085] This example uses human adenovirus type 3 and enterovirus type 71 as examples to illustrate the anti-adenovirus and enterovirus effects of the echinacea extract and the salvia miltiorrhiza extract of the present invention. Through the virus plaque test, the researchers screened out hundreds of plant extracts that have the best antiviral activity against human adenovirus type 3 and enterovirus 71, which are echinacea extract and salvia miltiorrhiza extract .

[0086] Figure 3A-3B Respectively show the antiviral effects of the water extract of Echinacea shoots of the present invention (EPA-W for short) to human adenovirus type 3 and enterovirus type 71; Figure 3C-3D The antiviral effects of the 70% ethanol extract (abbreviated as SMf-2-E) of the root and rhizome of Salvia miltiorrhiza of the present invention on human adenovirus type 3 and enterovirus type 71 are shown respectively. agai...

Embodiment 3

[0092] Antiviral activity of a composition containing an aqueous extract of Echinacea and an ethanol extract of Salvia miltiorrhiza

[0093] In this example, the antiviral activity of the combination of the water extract of Echinacea Echinacea and the ethanol extract of Salvia miltiorrhiza in different ratios was further verified by virus plaque test. Table 6 shows the composition of different proportions of the water extract of Echinacea shoots (abbreviated as EPA-W) and the 70% ethanol extract (abbreviated as SMf-2-E) of the roots and rhizomes of Salvia miltiorrhiza to combat human adenovirus type 3 and intestinal Effect of virus type 71. According to Table 6, the compositions obtained by mixing EPA-W and SMf-2-E in a ratio of 1:9 to 9:1 by weight all have very low IC50 and IC90. When EPA-W and SMf-2-E are mixed in a weight ratio of 3:7, the antiviral effects of the obtained composition on human adenovirus type 3 and enterovirus type 71 are as follows: Figure 4A and Fi...

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Abstract

The invention provides use of plant extracts for manufacturing an antiviral composition. The plant extract contains an Echinacea purpurea extract, a Salvia miltiorrhiza extract, or combinations thereof. The antiviral composition blocks adenoviruses and enterovirus infection through virucidal activity against adenovirus and inhibition of adenovirus and enterovirus attachment to and penetration intocells. Also provided is a method of preparing the antiviral composition resisting adenovirus and enterovirus.

Description

technical field [0001] The present invention relates to the use of a plant extract for the preparation of an antiviral composition and the preparation method of the antiviral composition, in particular to the use of Echinacea and Salvia miltiorrhiza extracts for the preparation of an antiviral composition and the The preparation method of the antiviral composition of cone flower and salvia miltiorrhiza extract. Background technique [0002] Since Enterovirus 71 (also referred to as EV71) was first discovered in California, USA in 1969, it is believed to be related to outbreaks in the United States, Europe, Australia, Japan, Brazil, and Malaysia. Before 1988, three severe outbreaks occurred in Bulgaria, Hungary, and Malaysia successively in 1975, 1978, and 1997, resulting in dozens of fatal cases. The most serious enterovirus 71 epidemic in the last century broke out in Taiwan, China in 1998. Statistical reports show that there were 129,106 cases of hand-foot-and-mouth dise...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P31/20A61P31/14
CPCA61K36/28A61K36/537A61K2236/331A61K2236/333A61K2300/00
Inventor 张銮英陈裕星
Owner 张銮英
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