Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition

An extract and echinacea technology are used in the preparation of antiviral compositions. Echinacea and Salvia miltiorrhiza extracts are used in the field of preparation of antiviral compositions, which can solve the problem of severe burden in children, worry about complications, and lack of enterovirus71 type and human adenovirus-specific antiviral drugs, etc., to reduce drug resistance and inhibit adenovirus and enterovirus infections

Active Publication Date: 2018-05-22
张銮英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, adenovirus infection leads to severe disease burden and worrisome complications in children
[0004] Cur

Method used

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  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition
  • Use of Echinacea and Salvia miltiorrhiza extract for manufacturing antiviral composition, and manufacturing method for antiviral composition

Examples

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Example Embodiment

[0064] Example 1

[0065] Preparation of plant extracts and analysis of index components

[0066] 1.1 Preparation method

[0067] This example illustrates the preparation method of the plant extract used in the preparation of the antiviral composition of the present invention. Echinacea extract and Salvia miltiorrhiza extract use water or alcohol-water mixture as the extraction solvent. The so-called alcohol-water mixture in the text refers to a mixture of various alcohols and water, such as methanol aqueous solution, ethanol aqueous solution, 2-propanol aqueous solution, wherein the volume ratio (v / v) of the alcohol to the alcohol-water mixture can be 1-95%. The extracts of different types of plants have similar preparation methods. The following uses the water extract of Echinacea and the 70% ethanol extract of Salvia as examples to illustrate the preparation steps of the water or alcohol extracts of the two plants.

[0068] In order to prepare the water extract of echinacea, the...

Example Embodiment

[0083] Example 2

[0084] Antiviral activity of echinacea extract and salvia miltiorrhiza extract

[0085] This example uses human adenovirus type 3 and enterovirus type 71 as examples to illustrate the effectiveness of the echinacea extract and salvia miltiorrhiza extract of the present invention against adenovirus and enterovirus. Through the virus plaque test, researchers screened hundreds of plant extracts that have the best antiviral activity against human adenovirus type 3 and enterovirus type 71 are echinacea extract and salvia miltiorrhiza extract .

[0086] Figure 3A-3B Respectively show the antiviral effect of the water extract of the echinacea of ​​the present invention (referred to as EPA-W) on human adenovirus type 3 and enterovirus type 71; Figure 3C-3D The 70% ethanol extracts (SMf-2-E for short) of the roots and rhizomes of the present invention respectively show the antiviral effects of human adenovirus type 3 and enterovirus type 71. against Figure 3A-3D Regres...

Example Embodiment

[0091] Example 3

[0092] Antiviral activity of the composition of the water extract of echinacea and the ethanol extract of Danshen

[0093] In this example, a virus plaque test was used to verify the antiviral activity of the water extract of echinacea of ​​the present invention and the ethanol extract of Salvia miltiorrhiza in different ratios. Table 6 shows the composition of different ratios of the water extract from the ground part of echinacea (EPA-W) and the 70% ethanol extract from the roots and rhizomes of Salvia miltiorrhiza (SMf-2-E) against human adenovirus type 3 and intestines The effect of virus 71. According to Table 6, the compositions obtained by mixing EPA-W and SMf-2-E in a weight ratio of 1:9 to 9:1 all have relatively low IC50 and anti-human adenovirus type 3 and enterovirus type 71 IC90. When EPA-W and SMf-2-E are mixed at a weight ratio of 3:7, the antiviral effects of the resulting composition on human adenovirus type 3 and enterovirus type 71 are as fo...

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Abstract

The invention provides use of plant extracts for manufacturing an antiviral composition. The plant extract contains an Echinacea purpurea extract, a Salvia miltiorrhiza extract, or combinations thereof. The antiviral composition blocks adenoviruses and enterovirus infection through virucidal activity against adenovirus and inhibition of adenovirus and enterovirus attachment to and penetration intocells. Also provided is a method of preparing the antiviral composition resisting adenovirus and enterovirus.

Description

technical field [0001] The present invention relates to the use of a plant extract for the preparation of an antiviral composition and the preparation method of the antiviral composition, in particular to the use of Echinacea and Salvia miltiorrhiza extracts for the preparation of an antiviral composition and the The preparation method of the antiviral composition of cone flower and salvia miltiorrhiza extract. Background technique [0002] Since Enterovirus 71 (also referred to as EV71) was first discovered in California, USA in 1969, it is believed to be related to outbreaks in the United States, Europe, Australia, Japan, Brazil, and Malaysia. Before 1988, three severe outbreaks occurred in Bulgaria, Hungary, and Malaysia successively in 1975, 1978, and 1997, resulting in dozens of fatal cases. The most serious enterovirus 71 epidemic in the last century broke out in Taiwan, China in 1998. Statistical reports show that there were 129,106 cases of hand-foot-and-mouth dise...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P31/20A61P31/14
CPCA61K36/28A61K36/537A61K2236/331A61K2236/333A61K2300/00
Inventor 张銮英陈裕星
Owner 张銮英
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