Sustained-release pharmaceutical composition for treating allergic rhinitis as well as preparation method and application thereof

Abstract

The invention relates to the technical field of rhinitis treatment medicines, and particularly discloses a sustained-release pharmaceutical composition for treating allergic rhinitis. The sustained-release pharmaceutical composition is prepared from the following raw materials according to the mass-volume concentration: 0.5 to 1.2 mg / ml of loratadine, 16 to 23 mg / ml of disodium cromoglycate, 0.1 to 0.25 mg / ml of dexamethasone, 8 to 15 mg / ml of ephedrine hydrochloride and 4 to 7 mg / ml of levofloxacin. The invention also discloses a preparation method of the sustained-release pharmaceutical composition for treating allergic rhinitis. The invention also discloses an application of the sustained-release pharmaceutical composition for treating allergic rhinitis. Aiming at the defects of allergic rhinitis natural environment pathogenic factors, complex variability of body autoimmune conditions, single clinical medicine component, poor nasal cavity adhesion, low bioavailability and the like,the medicine is prepared into a compound preparation according to a certain proportion, and a film agent is prepared by using a slow release technology to treat allergic rhinitis, so that the bioavailability and the curative effect of the medicine are improved.

Description

technical field [0001] The invention relates to the technical field of drugs for treating rhinitis, in particular to a slow-release drug for treating allergic rhinitis, a preparation method and application. Background technique [0002] Allergic rhinitis (AR), also known as allergic rhinitis, is a common allergic reaction in clinical practice. Its typical symptoms are nasal congestion, runny nose, sneezing and / or nasal itching. It is related to the effect, and there are a large number of patients at present, and the treatment is recurrent, protracted and unhealed, and the curative effect is not good. [0003] Although allergic rhinitis cannot be completely cured yet, through standardized comprehensive prevention and treatment, the symptoms of patients can be well controlled and the quality of life can be significantly improved. At present, the prevention and treatment of allergic rhinitis includes allergen avoidance, drug treatment and immune Three kinds of treatment: aller...

AI Technical Summary

Problems solved by technology

[0004] Among them, in drug treatment, choosing a single glucocorticoid, antihistamine, antileukotriene, mast cell membrane stabilizer, decongestant, anticholinergic nasal spray, and oral treatment can relieve symptoms, but long-term use will lead to drug resistance and Reduce curative effect; and nasal congestion is caused by turbinate edema, commonly used clinical sprays cannot be sprayed into the edema and it is difficult to attach to the affected area to improve curative effect, only oral preparations can be used to relieve edema, and oral preparations will cause side effects