Pharmaceutical composition with analgesic effect

A composition and drug technology, which can be used in drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve different problems, and achieve the effect of small dosage and good analgesic effect.

Inactive Publication Date: 2018-05-29
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the non-steroidal antipyretic and analgesic drug aspirin has anti-inflammatory and analgesic effects at the same time, not all drugs with anti-inflammatory effects must have analgesic effects, because the mechanisms of action of anti-inflammatory and analgesic drugs are different of

Method used

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  • Pharmaceutical composition with analgesic effect
  • Pharmaceutical composition with analgesic effect

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1 material

[0043] 1.1 Drugs

[0044] The whole herb of P. alba was picked in Huadu District, Guangzhou City. It was identified as P. alba (L.) DC by Yi Qifei, an associate researcher at South China Botanical Garden, Chinese Academy of Sciences.

[0045] Aspirin enteric-coated tablets, produced by Hunan Xinhui Pharmaceutical Co., Ltd., batch number 160102.

[0046] 1.2 Reagents

[0047] Glacial acetic acid, petroleum ether, ethyl acetate, chloroform, dimethyl sulfoxide, and n-butanol were all analytically pure. PBS and normal saline were homemade.

[0048] 1.3 Experimental animals

[0049] KM mice, male and female, SPF grade, single weight (20±2) g, were purchased from the Medical Experimental Animal Center of Southern Medical University, license number SCXK (Guangdong) 2011-0015.

[0050] 1.4 Instruments

[0051] One hundred thousandth electronic analytical balance (METTLER TOLEDO, XS205DU), electronic balance (Sartorius, BS124S), multifunctional ultrapure water s...

Embodiment 2

[0076] The whole herb of Bidens alba (Linn.) DC was dried and crushed, with a particle size of 25 mesh, and an ethanol solution with a concentration of 95% by volume was added according to the ratio of solid to liquid 1:8, and reflux extracted 3 times, 1 hour each time , combined extracts. Concentrate the extract under reduced pressure to a certain volume, remove chlorophyll by centrifugation, then continue to concentrate until there is no alcohol smell, then add an appropriate amount of distilled water to dissolve, first extract 3 times with 2 times the amount of petroleum ether, and combine the petroleum ether extract; then use 2 times the amount of extracted with chloroform three times, and combined the chloroform extracts. Concentrate under reduced pressure, remove the extractant, and vacuum-dry at 800 Pa and 45°C for 150 min to obtain the analgesic active extract of P. difficile.

[0077] The analgesic active extract powder of P. difficile is dissolved in dimethyl sulfox...

Embodiment 3

[0079] The whole herb of Bidens alba (Linn.) DC was dried and pulverized, the particle size was 25 mesh, and the ethanol solution with a concentration of 90% by volume was added according to the ratio of solid to liquid 1:10, and the reflux was extracted 3 times, each time for 1 hour , combined extracts. Concentrate the extract under reduced pressure to a certain volume, centrifuge to remove chlorophyll, then continue to concentrate until there is no alcohol smell, then add an appropriate amount of distilled water to dissolve, extract 3 times with 2 times the amount of petroleum ether, and combine the petroleum ether extract; extracted with chloroform three times, and combined the chloroform extracts. They were respectively concentrated under reduced pressure, and vacuum-dried at 800 Pa and 45° C. for 150 min to obtain the analgesic active extract of C. difficile.

[0080] The analgesic active extract powder of P. difficile is dissolved in dimethyl sulfoxide, and Tween-80 is ...

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Abstract

The invention discloses pharmaceutical composition with an analgesic effect and belongs to the field of pharmacy. The pharmaceutical composition is prepared from the effective ingredient of extractivewhich is obtained by further extracting Bidens alba(L.)DC herb alcohol extractive by an organic solvent. Researches show that when a petroleum ether part extractive concentration of the bidens alba is 12.0 or 60.0mg / kg and a chloroform part extractive concentration is 4.0 or 20.0mg / kg, a better analgesic effect on a mouse is achieved; especially, an analgesic effect of 60.0mg / kg petroleum ether part extractive is similar to that of 20mg / kg aspirin. The pharmaceutical composition with the analgesic effect disclosed by the invention can be dosed through an oral administration mode and is not only limited for parenteral administration. Compared with parenteral administration, the oral administration has the advantages of convenience in medicine administration, small harm to the body and highpatient compliance.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition with analgesic effect. Background technique [0002] Ghost needle grass is widely distributed in my country, and has a long history of folk medicine. It has the functions of clearing away heat, detoxification, dampness, and strengthening the spleen. Indications for colds, sore throat, jaundice hepatitis, summer-dampness vomiting and diarrhea, enteritis, dysentery, blood deficiency and yellow swelling, hemorrhoids, snake bites, etc. There are 233 species, 284 varieties and 148 subspecies of the genus Ghost needles, which are distributed in temperate and tropical regions all over the world. A total of 9 species and 2 varieties have been recorded in my country. [0003] Bidens alba (L.) DC is an annual or perennial herb of the genus Bidens alba (L.) DC. It is native to tropical America and is an invasive species in my country. It is mainly distribut...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K47/26A61P29/00
CPCA61K36/28A61K47/26A61K2236/15A61K2236/17A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 袁明贵徐志宏彭新宇黄婷张军丽高彪
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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