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Biological micro-nano robot based on biological 3D printing and construction method thereof

A technology of 3D printing and construction methods, applied in the direction of micro-manipulators, manipulators, program-controlled manipulators, etc., which can solve the problems of less exploration of biodegradability

Active Publication Date: 2018-06-01
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing bio-micro-nano robots are biocompatible, there is still little exploration in biodegradability, and this property is of great significance for expanding the application field of bio-fusion robots.

Method used

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  • Biological micro-nano robot based on biological 3D printing and construction method thereof
  • Biological micro-nano robot based on biological 3D printing and construction method thereof
  • Biological micro-nano robot based on biological 3D printing and construction method thereof

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Experimental program
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Effect test

Embodiment 1

[0019] Referring to Fig. 1, the biological micro-nano robot based on biological 3D printing includes a counterweight head (1) and a bio-micro-nano robot body, which is characterized in that: the counterweight head (1) is a hydrogel of a spherical or short cylindrical sphere Glue entity; the body of the biological micro-nano robot is a hydrogel microtube (4) with an empty channel structure, and its inner cavity can carry drugs (3); the counterweight head (1) is connected to the end of the robot body, close to the Driver cells (2) are inoculated at the neck of the hydrogel microtube (4) or at the head and tail of the hydrogel microtube (4); the outside world is equipped with a stimulating signal (5), and under the action of the stimulating signal (5), the driving cells produce corresponding contraction behavior , thus generating the driving force for the robot.

Embodiment 2

[0021] The biological micro-nano robot based on biological 3D printing and its construction method are used to prepare the above-mentioned robot. It is characterized in that it uses a biodegradable hydrogel material and adopts 3D printing technology to prepare the biological micro-nano robot body. Specifically, it can be used The hydrogel microtube (4) with hollow channel structure and the hydrogel entity as the weight head (1) are prepared based on the method of ion cross-linking forming; the use of self-shrinking and shrinking ability can be stimulated by external stimuli Regulated cells or tissues are inoculated on the neck of the robot body as the driving unit of the biological micro-nano robot; the driving unit of the biological micro-nano robot is: a) when the biological micro-nano robot is suspended in a liquid environment, the driving cells are inoculated At the connection between the counterweight head (1) and the hydrogel microtube (4), the contraction of the driving ...

Embodiment 3

[0023] The biological micro-nano robot and its construction method based on biological 3D printing are characterized in that the specific operation steps are as follows:

[0024] a. Prepare the hydrogel, and then prepare the weight head (1) and the hydrogel microtube (4) based on the ion cross-linking forming method;

[0025] b. Select the driver cell (2) species;

[0026] c. Select the stimulus signal type that matches the driver cell (2);

[0027] d. Inoculate the driving cells (2) to the positions set by the weight head (1) and / or the hydrogel microtube (4);

[0028] e. Place the biological micro-nano robot in the set environment, and place the stimulation signal (5).

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Abstract

The invention discloses a biological micro-nano robot based on biological 3D printing and a construction method thereof. The biological robot mainly comprises a hydrogel micropipe, a counterweight head, a driving cell, a stimulating signal and a drug carrying unit, wherein the counterweight head is connected with one end of the hydrogel micropipe. The construction method of the robot comprises thestep of forming once by adopting an ionic crosslinking biological 3D printing extrusion forming technique, wherein the drug carrying unit is the hydrogel micropipe all of or part of which contains drug. The robot adopts driving modes that when the biological micro-nano robot is suspended in a liquid environment, the driving cell is inoculated in the connecting position of the counterweight head and the hydrogel micropipe so as to drive the robot to move; when the biological micro-nano robot makes contact with the solid surface, the driving cell can be inoculated in the head and tail of the hydrogel micropipe so as to drive the robot to move. The robot is degraded after performing a task, so that the damage to an applied organism can be greatly reduced, and drug delivery and release are realized.

Description

technical field [0001] The invention relates to a biological micro-nano robot based on biological 3D printing and a construction method thereof, belonging to the field of micro-nano robots and special robots. Background technique [0002] Bio-micro-nano robots driven by cells and based on biomaterials have self-repair capabilities and strong safety characteristics, and have received more and more attention this year. [0003] At present, the cells widely used as the driving unit of biological micro-nano robots mainly include: mammalian cardiomyocytes, skeletal muscle cells, and insect back blood vessels. These cells have the property of spontaneous beating, and in the existing research, it is found that this beating property can be regulated by external stimulation signals, such as the stimulation of physical signals such as light, electricity, and magnetism, as well as the chemical stimulation of specific drugs, etc. . In addition, most of the machine body materials curre...

Claims

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Application Information

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IPC IPC(8): B25J7/00B25J9/16
CPCB25J7/00B25J9/1605
Inventor 刘媛媛连红军张毅汪羽蒲华燕孙翊刘娜杨扬
Owner SHANGHAI UNIV
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