A highly sensitive ion mobility spectrometer and method with ion confinement function

Abstract

The invention discloses a high-sensitivity ion mobility spectrometer with ion confinement function and a method. Two layers of parallel metal grids are used as ion gates, and the opening and closing of the ion gates are realized by regulating the voltage of the grids. When the ion gate is closed, the ions generated are trapped and stored between the two grids. When the ion gate is open, the stored ions are pushed into the migration region and then detected by the charge detector. In ion mobility spectrometry, within one cycle, the closing time of the ion gate is 50-100 times that of the opening time of the ion gate, that is, the number of ions produced during the closing time of the ion gate is 50-100 times the number of ions produced during the opening time of the ion gate. The invention confines, stores and detects the ions generated during the closing time of the ion gate, the signal strength can be increased by 1-2 orders of magnitude, the sensitivity of the ion mobility spectrum can be significantly improved, and the performance of the ion mobility spectrum can be improved.

Description

technical field [0001] The invention belongs to the field of analytical instruments and detection, and in particular relates to a highly sensitive ion mobility spectrometer with ion confinement function and a method. The ion mobility spectrometer adopts a special ion gate design, which can realize ion confinement and storage, and significantly improve the sensitivity of the mobility spectrometer. Background technique [0002] The ion gate is one of the core devices of the ion mobility spectrometer. Through the closing and opening of the ion gate, the ions in the reaction area can enter the migration area periodically, and are detected by the detector after separation. [0003] In a conventional ion mobility spectrometer, in a complete cycle, the closing time of the ion gate is usually 50-100 times the opening time, that is, the closing time is much longer than the opening time, but when detecting ions, the ion mobility spectrometer can only detect The number of ions passin...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: to overcome the difficulties of the small number of ions passing through and the low detection sensitivity when the ion gate is opened in the existing ion mobility spectrometer, and to provide a highly sensitive ion mobility spectrometer with ion confinement function and method, using a new type of ion gate with ion confinement ability can realize the confinement and storage of ions during the closing period of the ion gate, and improve the sensitivity of ion mobility spectrometry

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