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Vascular patch using silk matrix and method of manufacturing same

一种制造方法、基质的技术，应用在利用蚕丝基质的血管补片及其制造领域，能够解决炎症或组织坏死、不可能长时间发挥血管功能、低生物相容性等问题，达到降低制造成本、优异细胞培养能力、简单制造工艺的效果

Inactive Publication Date: 2018-06-08
REPUBLIC OF KOREA (MANAGEMENT RURAL DEV ADMINISTRATION)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, traditional vascular patches made of synthetic polymers (PET, ePTFE) or Gore-Tex cause vascular blockage due to thrombus formation and calcification due to bioincompatibility, making it impossible to perform vascular function for a long time
Furthermore, they are non-degradable materials and have low biocompatibility, which can undesirably cause inflammation or tissue necrosis
Also, such vascular patches are expensive and difficult to apply to the relatively thin blood vessels in the oral and maxillofacial regions because they are custom-made for cardiovascular applications

Method used

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  • Vascular patch using silk matrix and method of manufacturing same
  • Vascular patch using silk matrix and method of manufacturing same
  • Vascular patch using silk matrix and method of manufacturing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Production of the vascular patch 1 of the present invention

[0058] like figure 1 As shown, 15 mature silkworms were placed on a sheet gradually inclined at 20° relative to the ground. After 1 hour, the sheet was again gradually tilted in the opposite direction. In this way, silkworms weave cocoons while moving, producing figure 2 The silk matrix 10 of the configuration shown in A.

[0059] The above-mentioned tilting process was performed for one day, the balance was maintained for two days, and the above-mentioned tilting process was performed again, whereby silk substrates were produced from silkworms in about 3 days. The thickness of the silk matrix is ​​about 0.01 mm.

[0060] like image 3 As shown, the silk matrix 10 is cut with scissors to divide it planarly in a rectangular shape, thereby forming a silk matrix sheet 20, which is then sterilized to produce the vascular patch 1 of the present invention.

Embodiment 2

[0061] Production of the vascular patch 2 of the present invention

[0062] like figure 1 As shown, 30 mature silkworms were placed on a sheet gradually inclined at 20° relative to the ground. After 1 hour, the sheet was again gradually tilted in the opposite direction. In this way, silkworms weave cocoons while moving, producing figure 2 The silk matrix 10 of the configuration shown in B.

[0063] The above-mentioned tilting process was performed for one day, the balance was maintained for two days, and the above-mentioned tilting process was performed again, whereby silk substrates were produced from silkworms in about 3 days. The thickness of the silk matrix is ​​about 0.7 mm.

[0064] like Figure 4 As shown, the silk matrix 10 with a thickness of 0.7 mm is peeled off to perform thickness division, thereby forming a silk matrix part 30 with a thickness of 0.2 mm, which is then sterilized, thereby producing the vascular patch 2 of the present invention .

Embodiment 3

[0065] Production of the vascular patch 3 of the present invention

[0066] like figure 1 As shown, 30 mature silkworms were placed on the sheet, and the sheet was gradually inclined at 20° relative to the ground. After 1 hour, the sheet was again gradually tilted in the opposite direction. In this way, silkworms weave cocoons while moving, producing figure 2 The silk matrix 10 of the configuration shown in B.

[0067] The above-mentioned tilting process was performed for one day, the balance was maintained for two days, and the above-mentioned tilting process was performed again, whereby silk substrates were produced from silkworms in about 3 days. The thickness of the silk matrix is ​​about 0.7mm.

[0068] The silk matrix is ​​then cut so as to be planarly divided in a rectangular shape, whereby the silk matrix sheet 20 is formed.

[0069] like Figure 5 As shown, the silk matrix sheet 20 with a thickness of 0.7 mm was peeled off to perform thickness division, ther...

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Abstract

Disclosed are a vascular patch using a silk matrix and a method of manufacturing the same, wherein the vascular patch is configured such that a silk matrix having a cross-section with a first thickness, produced from silkworms, is subjected to planar division into two or more silk matrix pieces having a predetermined shape with the first thickness. Furthermore, the manufacturing process is relatively simple, thus reducing the manufacturing cost compared to when manufacturing typical vascular patches, and also, the vascular patch can exhibit outstanding cell culture capacity and is biocompatible.

Description

technical field [0001] The present invention relates to a vascular patch utilizing silk matrix and a manufacturing method thereof, more particularly, the present invention relates to a vascular patch utilizing silk matrix and a manufacturing method thereof, wherein the vascular patch is different from the existing vascular patch , is biocompatible, effectively maintains the inner diameter of blood vessels, and promotes the growth of vascular endothelial cells in vascular defects. Background technique [0002] In oral and maxillofacial surgery, vascular injury can occur during cervical lymph node dissection, oral cancer resection or reconstruction, maxillofacial trauma, or surgical resection of lesions close to major blood vessels. Possible treatments for vascular injury may include ligation of the damaged vessel or direct closure of the vascular defect. However, various complications such as cerebral infarction, etc., are reported to occur with high frequency when a large b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61F2/00A61F2/06
CPCA61F2/0063A61F2/06A61F2230/0019A61F2240/001A61L27/3604A61L27/507
Inventor 权海龙赵柳英李光吉金基荣
Owner REPUBLIC OF KOREA (MANAGEMENT RURAL DEV ADMINISTRATION)
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