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Viral liver disease treating pharmaceutical composition

A viral liver disease and composition technology, applied in the field of pharmacy, can solve the problems of being unable to effectively enrich active ingredients, hindering mass processing and industrial production, and being unable to be widely purchased

Active Publication Date: 2018-06-15
泰凌(中国)投资有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of raw materials of Chinese medicinal materials used in this formula, and the active ingredients in the raw materials cannot be effectively enriched by the preparation method in patent CN00113403.5
Moreover, gardenia root is a local standard medicinal material in Hunan, which has not been included in the national pharmacopoeia, so it cannot be widely purchased, which hinders mass processing and industrial production

Method used

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  • Viral liver disease treating pharmaceutical composition
  • Viral liver disease treating pharmaceutical composition
  • Viral liver disease treating pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1, medicine preparation: pill A

[0073] raw material:

[0074]Gardenia 130g, Poria 129g, Salvia miltiorrhiza 90g, Digupi 108g, Pseudostellaria 90g, Amomum 57g. The finished product prepared from the above raw materials is 100g.

[0075] Preparation:

[0076] The amomum was crushed, and 392g (7 times) of water was added to extract the volatile oil for 2h, and the oil was collected. Take β-cyclodextrin (β-CD) 4 times the amount of collected oil and dissolve it with 15 times water, stir and clathrate at 45°C, cool to room temperature for later use.

[0077] Gardenia and red ginseng were reflux extracted with 5 times the amount of 70% (v / v) ethanol for 1.5 hours, filtered to obtain the filtrate, which was concentrated in vacuum to an alcohol extraction paste with a relative density of 1.2 (measured at 70°C), and set aside.

[0078] Poria cocos is dried, pulverized, and passed through a 120-mesh sieve to obtain Poria cocos coarse powder. Take Poria cocos pow...

Embodiment 2

[0080] Embodiment 2, medicine preparation: pill B

[0081] raw material:

[0082] Gardenia 110g, Poria 158g, Danshen 96g, Digupi 135g, Pseudostellaria 98g, Amomum 55g. The finished product prepared from the above raw materials is 100g.

[0083] Preparation:

[0084] 55g of amomum was crushed, and 9 times of water was added to extract the volatile oil for 2 hours, and the oil was collected. Take β-cyclodextrin (β-CD) twice as much as the collected oil and dissolve it with 11 times water, stir and clathrate at 40°C for 1.5h, and cool to room temperature for later use.

[0085] Gardenia and red ginseng 7 times the amount of 80% ethanol reflux extraction for 1.2h, filtered, plus 2 times of 70% ethanol extraction for 1.5h, filtered, the obtained medicinal residues were retained, the filtrates were combined twice, concentrated in vacuo to relative Density is 1.2 (measured at 70 ℃) alcohol extraction cream, set aside.

[0086] Poria cocos is dried and pulverized to obtain Poria ...

Embodiment 3

[0088] Embodiment 3, medicine preparation: pill C

[0089] raw material:

[0090] Gardenia 155g, Poria 110g, Salvia miltiorrhiza 88g, Digupi 120g, Radix Pseudostellariae 100g, Amomum 50g. The finished product prepared from the above raw materials is 100g.

[0091] Preparation:

[0092] Crush 50g of amomum, add 8 times of water to extract the volatile oil for 1 hour, collect the oil, filter to obtain the filtrate and dregs for later use. Then take β-cyclodextrin (β-CD) which is 5 times the amount of the collected oil and dissolve it with 17 times the amount of water, and mix with the collected Amomum volatile oil at 50°C for 3 hours, then cool to room temperature for later use.

[0093] Gardenia and Radix Ginseng 5 times the amount of 85% ethanol reflux extraction for 4 hours, filtered, plus 4 times the amount of 85% ethanol extraction for 1.5 hours, filtered, combined two filtrates, concentrated in a vacuum to a relative density of 1.2 (at 70 ° C Determination) of the alco...

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PUM

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Abstract

The present invention relates to a viral liver disease treating pharmaceutical composition, and discloses a traditional Chinese medicine composition, which is prepared from cape jasmine, tuckahoe, salvia miltiorrhiza, cortex lycii, radix pseudostellariae and amomum villosum lour through a suitable preparation method. According to the present invention, the traditional Chinese medicine compositionhas advantages of low raw material cost, easily-available raw materials and simple preparation method, and can significantly reduce the viral amount of viral hepatitis and improve the function of liver cells.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically, the invention relates to a pharmaceutical composition for treating viral liver disease. Background technique [0002] Viral hepatitis, including types A, B, C, D, and E, belongs to the statutory category B infectious diseases. It is highly contagious, has complex transmission routes, wide prevalence, high incidence, and is a great hazard to people's health. Among them, some patients with hepatitis B, C, and D can evolve into chronic diseases, and may develop into liver cirrhosis and liver cancer, which will cause greater harm. [0003] Viral hepatitis A (referred to as hepatitis A) is an acute digestive tract infectious disease caused by hepatitis A virus (HAV: hepatitis A virus), which mainly causes liver damage. Although the incidence of hepatitis A has been decreasing year by year since 1990, the incidence and prevalence of hepatitis A is still a serious public health problem in...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K47/69A61P31/14A61P31/20A61P1/16A61P35/00
CPCA61K9/2068A61K9/2806A61K36/076A61K36/36A61K36/537A61K36/744A61K36/815A61K36/9064A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 不公告发明人
Owner 泰凌(中国)投资有限公司
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