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Method of extracting dendrobine from dendrobium candidum

A technology for dendrobium officinale and dendrobine, which is applied in the field of extraction of Dendrobium officinale, can solve the problems of low extraction rate of dendrobine, restrict the development and utilization of active components of dendrobium candidum, etc., and achieves the effect of high extraction rate

Active Publication Date: 2018-06-15
贵州独秀峰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the extraction of dendrobine has certain limitations, which makes the extraction rate of dendrobine low, which limits the development and utilization of active ingredients of dendrobine.

Method used

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  • Method of extracting dendrobine from dendrobium candidum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The method for extracting dendrobine in dendrobium officinale comprises the following steps:

[0068] ① Take Dendrobium candidum, pulverize it, add water to Dendrobium candidum according to the material-to-liquid ratio of 1:12, and obtain product A;

[0069] ②A product is adjusted to pH=9 with saturated lime water;

[0070] ③ Product B was extracted by microwave three times at a power of 310W, each time for 18 minutes, and the extracts were combined to obtain Product C;

[0071] ④ Filtration of product C, the filtrate was concentrated twice, the first time the vacuum degree was controlled to be 0.07-0.08MPa, the second time the vacuum degree was controlled to be 0.08-0.09MPa, and the vacuum concentration time of both times was 8min to obtain product D;

[0072] ⑤ Add 3 times the amount of ethanol to product D, and place it at 1-4°C for 11 hours to obtain product E;

[0073] ⑥Filter product E, wash the precipitate with ethanol 3-4 times, and dry to constant weight.

Embodiment 2

[0075] The method for extracting dendrobine in dendrobium officinale comprises the following steps:

[0076] ① Take Dendrobium candidum, pulverize it, add water to Dendrobium candidum according to the material-to-liquid ratio of 1:10, and obtain product A;

[0077] ②A product is adjusted to pH=9 with saturated lime water;

[0078] ③Product B was extracted by microwave three times at a power of 320W for 20 minutes each time, and the extracts were combined to obtain Product C;

[0079] ④ Filtration of product C, the filtrate is concentrated twice, the first control vacuum degree is 0.07-0.08MPa, the second control vacuum degree is 0.08-0.09MPa, and the vacuum concentration time of both times is 10min to obtain product D;

[0080] ⑤ Add 4 times the amount of ethanol to product D, and place it at 1-4°C for 12 hours to obtain product E;

[0081] ⑥ Product E was filtered, the precipitate was washed 4 times with ethanol, and dried to constant weight.

Embodiment 3

[0083] The method for extracting dendrobine in dendrobium officinale comprises the following steps:

[0084] ① Take Dendrobium candidum, pulverize it, add water to Dendrobium candidum according to the material-to-liquid ratio of 1:14, and obtain product A;

[0085] ②A product is adjusted to pH=9 with saturated lime water;

[0086] ③Product B was extracted by microwave three times at a power of 300W, each time for 15 minutes, and the extracts were combined to obtain Product C;

[0087] ④ Filtrate product C, concentrate the filtrate twice, control the vacuum degree for the first time to 0.07-0.08MPa, and control the vacuum degree for the second time to 0.08-0.09MPa, and the vacuum concentration time for both times is 5min to obtain product D;

[0088] ⑤ Add 3 times the amount of ethanol to product D, and place it at 1-4°C for 10 hours to obtain product E;

[0089] ⑥ Product E was filtered, the precipitate was washed 3 times with ethanol, and dried to constant weight.

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Abstract

The invention discloses a method of extracting dendrobine from dendrobium candidum. The method comprises the steps of: (1) grinding and adding the dendrobium candidum into water according to a material-liquid ratio of 1:(10-14) to form a product A, (2) regulating a pH (potential of hydrogen) of the product A to 9, (3) performing microwave extraction for thrice, 15-20min each time, on a product B,at power of 300-320W, and merging extracts to form a product C, (4) filtering the product C and performing vacuum concentration on a filtrate to form a product D, (5) adding 3-4 times of alcohol intothe product D, and putting at 1-4 DEG C for 10-12h to form a product E, and (6) filtering the product E, washing a sediment with alcohol for 3-4 times, and drying to the constant weight. When the technology is used for extracting the dendrobium candidum, an extraction rate of the dendrobine is high, and the exploitation and utilization of the dendrobine of the dendrobium candidum are promoted.

Description

technical field [0001] The invention relates to a method for extracting dendrobium officinale, in particular to a method for extracting dendrobine from dendrobium officinale. Background technique [0002] Dendrobium officinale, also known as Tiepilan, Chlorophytum, Yunnan Tiepi, Chlorophytum officinale, is a perennial herb of the genus Dendrobium orchidaceae. Dendrobium officinale is a top-grade medicinal material of Dendrobium. Contains active ingredients such as dendrobine, dendrobine, alkaloids, etc. It has the functions of nourishing yin and clearing heat, promoting body fluid and benefiting stomach, moisturizing throat and improving eyesight. It has good curative effect on anti-platelet aggregation, lowering blood sugar and treating cataract. [0003] Modern pharmacological studies have shown that Dendrobium officinale can enhance both non-specific and specific immunity, and has significant pharmacological effects in anti-tumor, anti-oxidation, lowering blood sugar and...

Claims

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Application Information

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IPC IPC(8): C07D491/08
CPCC07D491/08
Inventor 倪石寿
Owner 贵州独秀峰药业有限公司
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