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A kind of high barrier PVC medicinal hard sheet and preparation method thereof

A high-resistance, hard film technology, applied in the formulation and preparation of high-resistance PVC pharmaceutical hard film, can solve problems such as difficult to meet market demand, and achieve the effects of good barrier property, guaranteed quality, and strong barrier rate

Active Publication Date: 2021-03-26
GUIZHOU CHIEN YEH PLASTIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is due to the fact that there are many complicated factors in the production process of the blister, which makes it difficult to meet the market demand

Method used

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  • A kind of high barrier PVC medicinal hard sheet and preparation method thereof
  • A kind of high barrier PVC medicinal hard sheet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A high-impermeability PVC pharmaceutical hard tablet formulation is composed of the following raw materials in parts by mass: PVC 100g, LD 1500.8g, anti-impact agent 4.0g, EVA 0.4g, stabilizer 1.0g, lubricant 0.1g, plasticizer 0g.

[0026] The PVC is obtained by mixing the quality of SG-7 premium product, SG-8 premium product and the like.

[0027] The LD150 mentioned above is an extrusion-grade LDPE with a melt index ≤ 1.0.

[0028] Described EVA, its VA content is 45%.

[0029] The stabilizer is mercaptan organotin SW977.

[0030] Described lubricant is polyethylene wax.

[0031] The described high-barrier PVC pharmaceutical hard sheet comprises the following preparation steps:

[0032] 1) PVC, LD150, and EVA are dried and mixed, extruded and granulated by a twin-screw extruder to obtain high-barrier PVC masterbatch;

[0033] 2) Put the high-impermeability PVC masterbatch and the remaining additives in a high-temperature mixer, dry at 105°C for 10 minutes, and at ...

Embodiment 2

[0036] A high-impermeability PVC pharmaceutical hard tablet formulation is composed of the following raw materials in parts by mass: 100g PVC, 4.0g LD150, 5.0g anti-impact agent, 2g EVA, 1.2g stabilizer, 0.4g lubricant, and 0.3g plasticizer.

[0037] The PVC is made by mixing TL800, TY800 and other qualities.

[0038] The LD150 mentioned above is an extrusion-grade LDPE with a melt index ≤ 1.0.

[0039] Described EVA, its VA content is 60%.

[0040] The stabilizer is mercaptan organotin DX181.

[0041] Described lubricant is the quality mixture such as calcium stearate, stearic acid.

[0042] The described high-barrier PVC pharmaceutical hard sheet comprises the following preparation steps:

[0043] 1) PVC, LD150, and EVA are dried and mixed, extruded and granulated by a twin-screw extruder to obtain high-barrier PVC masterbatch;

[0044] 2) Put the high-barrier PVC masterbatch and the remaining additives in a high-temperature mixer, dry at 105°C for 10 minutes, and dry at...

Embodiment 3

[0047] A high-impermeability PVC pharmaceutical hard tablet formulation is composed of the following raw materials in parts by mass: 100g of PVC, 8.0g of LD150, 6.0g of anti-impact agent, 4.0g of EVA, 1.3g of stabilizer, 2g of lubricant, and 0.5g of plasticizer.

[0048] Said PVC is made by mixing SG-7 high-quality products, SG-8 high-quality products, TL800, TY800 and other qualities.

[0049] The LD150 mentioned above is an extrusion-grade LDPE with a melt index ≤ 1.0.

[0050] Described EVA, its VA content is 75%.

[0051] The stabilizer is a mixture of medium quality mercaptan organotin SW977 and DX181.

[0052] The lubricant is formed by mixing polyethylene wax, calcium stearate, stearic acid and the like.

[0053] The described high-barrier PVC pharmaceutical hard sheet comprises the following preparation steps:

[0054] 1) PVC, LD150, and EVA are dried and mixed, extruded and granulated by a twin-screw extruder to obtain high-barrier PVC masterbatch;

[0055] 2) Put...

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Abstract

The invention belongs to the technical field of pharmaceutical production, and specifically relates to a formula for a high-barrier pharmaceutical PVC hard sheet. The high-barrier pharmaceutical PVC hard sheet is composed of the following raw materials in parts by mass: PVC, LD150, an impact resistant agent, EVA, a stabilizer, a lubricant, a filling agent and a plasticizer. According to the invention, through a certain raw material proportion, the pharmaceutical PVC hard sheet prepared according to the formula provided by the invention has strong barrier rate, and can reach a minimum oxygen permeation rate of 3.7 cm3 / (m2.24h.0.1Mpa) and a minimum water vapor permeation rate of 1.37 g / (m2.24h). According to the invention, when the PVC hard sheet is prepared into a blister pack, the water vapor permeation rate of the blister pack is measured to in a variation range of 0.01 to 0.04 g / (m2.24h).

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production, and in particular relates to a formulation of a high-barrier PVC medical hard sheet and a preparation method thereof. Background technique [0002] Blister packaging of medicines is also called PTP packaging (pressthrough packaging), which is widely used in solid preparations such as tablets, pills, suppositories, and capsules because it is easy to carry, small doses and serialized packaging. Medicines are very sensitive to water vapor, oxygen, and light, and are prone to failure due to moisture absorption. To maintain the efficacy of the product, blister packs must have very good barrier properties. [0003] The foaming substrate of the blister is mainly made of polyvinyl chloride (PVC) hard sheet, polyvinylidene chloride (PVC / PVDC) hard sheet and other composite materials, and the cost of PVC / PVDC hard sheet is high and the process is complicated. It not only increases the i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L27/06C08L23/08C08L31/04C08L23/06C08K5/00C08K5/58C08K5/09C08K5/098
CPCC08L27/06C08L2201/14C08L2205/025C08L2205/035C08L2207/066C08L23/0853C08L23/06C08K5/58C08L31/04C08K5/09C08K5/098C08K5/00
Inventor 陈洋郑文学胡红群田敏
Owner GUIZHOU CHIEN YEH PLASTIC