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Application of biomarkers in the diagnosis of neuroendocrine tumors of the small intestine

A neuroendocrine and small intestine technology, applied in the direction of analytical materials, instruments, measuring devices, etc., can solve the problems of low sensitivity and specificity of SI-NENs

Active Publication Date: 2020-11-06
SHANGHAI PUDONG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the shortcomings of low sensitivity and specificity in diagnosing SI-NENs using biomarkers alone in the prior art, and to provide a plasma biomarker that is not only simple, but also has high sensitivity and high specificity composition

Method used

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  • Application of biomarkers in the diagnosis of neuroendocrine tumors of the small intestine
  • Application of biomarkers in the diagnosis of neuroendocrine tumors of the small intestine
  • Application of biomarkers in the diagnosis of neuroendocrine tumors of the small intestine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Comparison of Example 1 Plasma CgA Test and Pathological Diagnosis Results

[0048] Pathological results were positive in 38 cases and negative in 56 cases. Diagnosed with plasma CgA alone, 49 cases had negative results, including 40 cases of true negatives, 9 cases of false negatives, and 45 cases of positive results, of which 29 cases were true positives and 16 cases of false positives. See Table 3.

[0049] Table 3 Comparison of plasma CgA test and pathological diagnosis results

[0050]

Embodiment 2

[0051] Comparison of Example 2 Plasma Midkine Test and Pathological Diagnosis Results

[0052] Using plasma Midkine alone for diagnosis, 42 cases had negative results, including 34 cases of true negatives, 8 cases of false negatives, and 52 cases of positive results, of which 30 cases were true positives and 22 cases of false positives. See Table 4.

[0053] Table 4 Comparison of diagnostic results between plasma Midkine test and pathological gold standard

[0054]

[0055]

Embodiment 3

[0056] Example 3 Comparison of plasma DcR3 test and pathological diagnosis results

[0057] Diagnosed with plasma DcR3 alone, 45 cases had negative results, including 31 cases of true negatives, 14 cases of false negatives, and 49 cases of positive results, of which 24 cases were true positives and 25 cases of false positives. See Table 5.

[0058] Table 5 Comparison of diagnostic results between plasma DcR3 test and pathological gold standard

[0059]

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Abstract

The invention discloses a biomarker for detecting small intestine neuroendocrine tumors. The biomarker comprises CgA and Midkine. The invention also discloses a kit. The kit comprises an antibody fordetecting CgA and an antibody for detecting Midkine. The invention also discloses a kit composition. The kit composition comprises a kit for detecting CgA and a kit for detecting Midkine. The invention also discloses a use of the kit or kit composition in preparation of a preparation for detecting small intestine neuroendocrine tumors. The biomarker composition is used for plasma (including serumsamples) detection or diagnosis of the small intestine neuroendocrine tumors. The method is non-invasive, is easy to operate and has the characteristics of high sensitivity and high specificity.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of a combination of biomarkers in the detection / diagnosis of small intestinal neuroendocrine tumors. Background technique [0002] Neuroendocrine tumors are a group of heterogeneous tumors originating from endoderm neuroendocrine cells, among which gastroenteropancreatic neuroendocrine tumor (GEP-NET) is the most common pathological type. In 2010, WHO made the latest revision to the nomenclature and classification of neuroendocrine neoplasms (NENs), and divided NENs into four categories: neuroendocrine tumors (neuroendocrine tumors, NETs), neuroendocrine carcinomas (neuroendocrine carcinomas, NECs), Mixed adenoneuroendocrine carcinoma (MANEC) and site-specific and functional neuroendocrine tumors. Small intestinal neuroendocrine neoplasms (SI-NENs) are tumors derived from the APUD cell line of the small intestine. In the past, SI-NENs were considered to be a rare tum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57407G01N33/57446G01N33/57484
Inventor 杨涛高黎黎余波
Owner SHANGHAI PUDONG HOSPITAL
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