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A drug-loaded artificial bone material for repairing bone defects and its preparation method

An artificial bone and bone defect technology, applied in the field of orthopedic materials, can solve the problems of unsatisfactory slow release effect of growth factors and easy degradation, achieve good biocompatibility and osteoconductive ability, promote repair and growth, and long-term release. Effect

Active Publication Date: 2021-05-04
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, with the continuous advancement of tissue engineering technology, the construction of tissue-inductive bone repair materials has become a research hotspot. However, the use of bone growth-related factors to construct tissue-inducible bone repair materials has unsatisfactory slow-release effects of growth factors and is prone to Degradation and other deficiencies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]Preparation of amino-modified icariin: Add 1mL tetrahydrofuran and 0.5mL pyridine into 200mL double-distilled water and stir well, then add 1mmoL icariin and stir until completely dissolved, then add 1mmoL tert-butyloxycarbonylglycine tert-butyl ester, After rapid stirring for 1.5 h, slowly add 1 mL of tetrahydrofuran solution containing 1.5 wt % dicyclohexylcarbodiimide and 0.5 wt % dimethylaminopyridine dropwise, stir for 24 h, add double distilled water, suction filter, double distilled water Wash the filter residue, remove insolubles as much as possible, concentrate the solution by rotary evaporation, and then precipitate the concentrated solution in water, then add a tetrahydrofuran solution containing 1.5wt% dicyclohexylcarbodiimide and 0.5wt% dimethylaminopyridine , freeze overnight, remove the insoluble matter, concentrate, add double distilled water to precipitate the precipitate, and repeat this operation four times to obtain the product of the dehydration conde...

Embodiment 2

[0036] The preparation of amino-modified icariin is the same as in Example 1.

[0037] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.

[0038] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and perform plasma treatment for 10 minutes under the regulation of oxygen flow rate 90sccm, pressure 4Pa, and power 110W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7 hours, stir for 5 minutes every 1 hour during soaking, filter, wash, vacuum at 50-55°...

Embodiment 3

[0043] The preparation of amino-modified icariin is the same as in Example 1.

[0044] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.

[0045] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and conduct plasma treatment for 9 minutes under the regulation of oxygen flow rate 85sccm, pressure 4Pa, and power 115W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7.5h, stir for 5min every 1h during soaking, filter and wash, 50~55℃ Vacuum drying to o...

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PUM

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Abstract

The invention relates to the technical field of orthopedic materials, in particular to a drug-loaded artificial bone material for repairing bone defects and a preparation method thereof, comprising the following raw materials in parts by weight: 5-10 parts of drug-loaded microspheres, 60 parts of composite gel particles ~70 parts, 10~16 parts of biphasic calcium phosphate powder, 2.5~4 parts of collagen, the drug-loaded microsphere is a compound of hyaluronic acid and modified icariin, and the modified icariin Amino modified icariin, the composite gel particle is a compound of modified chitosan and modified loofah, and the mass ratio of modified chitosan and modified loofah is 1~2: 1. The drug-loaded artificial bone material of the present invention mixes aminoicariin, which promotes the secretion of osteoblast alkaline phosphatase, bone calcification and bone formation, with hyaluronic acid, releases its medicinal properties slowly, and continuously promotes the repair and growth of defective bone tissue; in addition , and also plays the role of antibacterial and anti-inflammatory by modifying chitosan; in addition, the artificial bone material is degradable and has good bioidentity.

Description

technical field [0001] The invention relates to the technical field of orthopedic materials, in particular to a drug-loaded artificial bone material for repairing bone defects and a preparation method thereof. Background technique [0002] Bone is an important tissue and organ in the human body that undertakes life activities. According to incomplete statistics, more than 3 million people suffer from various orthopedic diseases every year due to accident trauma, tumors and human congenital defects. Bone is the second most demanded graft after blood. Bone defect is a very common clinical trauma, and the bone repair process is very long, mainly including the hematoma and inflammation phase, the initial callus reaction phase, the cartilage formation phase, and the bone formation and remodeling phase. In the process of bone repair, cells secrete a variety of growth factors to play a role in different timing to ensure the repair of bone defects. [0003] Clinically, when a bone...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/24A61L27/20A61L27/12A61L27/18A61L27/54A61L27/58A61K38/39A61K9/16A61P19/08A61K31/7048A61K31/728A61K31/722A61K36/42
CPCA61K31/7048A61K31/722A61K31/728A61K36/42A61K38/39A61L27/12A61L27/18A61L27/20A61L27/24A61L27/3604A61L27/3637A61L27/54A61L27/58A61L2300/236A61L2300/252A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2430/02C08L5/08C08L71/02C08L67/04A61K2300/00
Inventor 马坤龙
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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