A drug-loaded artificial bone material for repairing bone defects and its preparation method
An artificial bone and bone defect technology, applied in the field of orthopedic materials, can solve the problems of unsatisfactory slow release effect of growth factors and easy degradation, achieve good biocompatibility and osteoconductive ability, promote repair and growth, and long-term release. Effect
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Embodiment 1
[0029]Preparation of amino-modified icariin: Add 1mL tetrahydrofuran and 0.5mL pyridine into 200mL double-distilled water and stir well, then add 1mmoL icariin and stir until completely dissolved, then add 1mmoL tert-butyloxycarbonylglycine tert-butyl ester, After rapid stirring for 1.5 h, slowly add 1 mL of tetrahydrofuran solution containing 1.5 wt % dicyclohexylcarbodiimide and 0.5 wt % dimethylaminopyridine dropwise, stir for 24 h, add double distilled water, suction filter, double distilled water Wash the filter residue, remove insolubles as much as possible, concentrate the solution by rotary evaporation, and then precipitate the concentrated solution in water, then add a tetrahydrofuran solution containing 1.5wt% dicyclohexylcarbodiimide and 0.5wt% dimethylaminopyridine , freeze overnight, remove the insoluble matter, concentrate, add double distilled water to precipitate the precipitate, and repeat this operation four times to obtain the product of the dehydration conde...
Embodiment 2
[0036] The preparation of amino-modified icariin is the same as in Example 1.
[0037] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.
[0038] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and perform plasma treatment for 10 minutes under the regulation of oxygen flow rate 90sccm, pressure 4Pa, and power 110W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7 hours, stir for 5 minutes every 1 hour during soaking, filter, wash, vacuum at 50-55°...
Embodiment 3
[0043] The preparation of amino-modified icariin is the same as in Example 1.
[0044] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.
[0045] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and conduct plasma treatment for 9 minutes under the regulation of oxygen flow rate 85sccm, pressure 4Pa, and power 115W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7.5h, stir for 5min every 1h during soaking, filter and wash, 50~55℃ Vacuum drying to o...
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