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Applications of staurosporine in resistance of Coccidiosis in chicken

A staurosporine and chicken coccidiosis technology, which is applied in the field of biomedicine, can solve the problems of no new drugs available and the slow speed of new drug development, and achieve the effects of alleviating serious drug resistance problems, speeding up research and development, and achieving obvious effects

Inactive Publication Date: 2018-07-13
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the anticoccidial drugs are mostly chemical products and antibiotic products. With the long-term use of these drugs, chicken coccidia have developed very serious drug resistance, and the development of new drugs is very slow, resulting in the current chicken industry. No new drugs are available, so there is an urgent need for new anticoccidial drugs to come to market

Method used

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  • Applications of staurosporine in resistance of Coccidiosis in chicken
  • Applications of staurosporine in resistance of Coccidiosis in chicken
  • Applications of staurosporine in resistance of Coccidiosis in chicken

Examples

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Embodiment 1

[0014] 1. Reproduction of chicken coccidia oocysts Take 20 Lingnan yellow broiler chickens aged 14 days orally inoculated with fresh sporulated oocysts of E.tenella GD strain, and each chicken was inoculated with 5×10 4 After 7.5 days, the test chickens were killed, the feces were collected, and the chicken coccidia oocysts were purified and collected by the saturated brine floating method, and the oocysts were resuspended with 2.5% (w / v) potassium dichromate solution, and placed in 28-30 Cultivate with shaking in a water bath at ℃ for 24-48 hours. When the sporulation rate reaches over 80%, count the oocysts and store them at 2-8℃ for later use.

[0015] 2. Purification of sporulated oocysts of chicken coccidia Centrifuge the sporulated oocysts at 4000rpm / min for 10min, discard the potassium dichromate solution, resuspend the oocysts with double distilled water until the potassium dichromate solution is completely cleaned; The sac precipitate was resuspended in 30% (v / v) sodi...

Embodiment 2

[0036] 1. Reproduction of chicken coccidia oocysts Take 20 Lingnan yellow broiler chickens aged 14 days orally inoculated with fresh sporulated oocysts of E.tenella GD strain, and each chicken was inoculated with 5×10 4After 7.5 days, the test chickens were killed, the feces were collected, and the chicken coccidia oocysts were purified and collected by the saturated brine floating method, and the oocysts were resuspended with 2.5% (w / v) potassium dichromate solution, and placed in 28-30 Cultivate with shaking in a water bath at ℃ for 24-48 hours. When the sporulation rate reaches over 80%, count the oocysts and store them at 2-8℃ for later use.

[0037] 2. Grouping Weigh the 14-day-old Lingnan yellow broiler chickens one by one, eliminate weak chicks and overweight chicks, divide 180 chicks with uniform weight into 6 groups randomly, 30 chickens in each group, and adjust the total weight of chicks in each group to be roughly equal ,Record data. After grouping, except Group I...

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Abstract

The invention discloses applications of staurosporine in resistance of Coccidiosis in chicken. According to the present invention, staurosporine can be uniformly mixed with an acceptable auxiliary material, and the obtained mixture can be added to a feed so as to effectively resist the reproduction of Coccidiosis in chicken; compared to the conventional anticoccidial drug sulfachloropyrazine sodium soluble powder, the product of the present invention has the significant anticoccidial effect; and with staurosporine, the serious drug resistance problem caused by the use of anticoccidial drugs inthe current breeding industry can be effectively alleviated, the research and development of new drugs on the basis can be accelerated, and the important benefits can be provided for the environmentally friendly and healthy development of breeding industry.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of staurosporine in resisting chicken coccidiosis. Background technique [0002] Sturosporine, alias: staurosporine, streptomyces staurosporine, staurosporine, staurosporine, is an indolecarbazole alkaloid isolated from the culture medium of Staurosptomyces staurosporeus. The compound is light yellow powder, easily soluble in DMSO, methanol, ethanol, insoluble in water. The molecular formula of the compound is: C 28 h 26 N 4 o 3 , molecular weight: 466.53, CAS accession number: 62996-74-1. Staurosporine has a variety of pharmacological activities, such as anti-tumor, anti-fungal, anti-bacterial, inhibition of platelet aggregation, inhibition of smooth muscle contraction activity, inhibition of protein kinase and promotion of cell mutation and other activities. [0003] Chicken coccidiosis (Coccidiosis) is an infectious disease caused by coccidia of the genus Eimer...

Claims

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Application Information

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IPC IPC(8): A61K31/553A61P33/02
CPCA61K31/553
Inventor 吴彩艳廖申权孙铭飞李娟戚南山吕敏娜林栩慧胡俊菁
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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