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Application of a kind of moutan cortex charcoal natural product in the preparation of anticoagulant medicine

An anticoagulant and drug technology, applied in the field of preparation of anticoagulant drugs, can solve problems such as no anticoagulant effect

Active Publication Date: 2021-06-22
云浮市厚德中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Charcoal medicine is a traditional medicine in traditional Chinese medicine. Stir-fried charcoal is stable, and fried charcoal is the classic theory of charcoal medicine. On the one hand, after frying charcoal, it produces or increases the hemostatic effect, and on the other hand, it retains the original medicinal properties of the medicine. It is isolated from Moutan bark charcoal. A new natural product - compound 1, has better anticoagulant effect, and there is no report on the anticoagulant effect of compound 1 of the present invention

Method used

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  • Application of a kind of moutan cortex charcoal natural product in the preparation of anticoagulant medicine
  • Application of a kind of moutan cortex charcoal natural product in the preparation of anticoagulant medicine
  • Application of a kind of moutan cortex charcoal natural product in the preparation of anticoagulant medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, compound anticoagulant effect experiment of the present invention

[0023] 1 main material

[0024] 1) Main reagents and instruments

[0025] Activated partial thromboplastin time (APTT) detection kit (lot number: 557216A), fibrinogen content (FIB) detection kit (lot number: 46144) and thrombin time (TT) (lot number: 46582) detection kit, all purchased from Sysmex Medical Electronics Co., Ltd.

[0026] CA-1500 automatic coagulation instrument (SYSMEX); TGL-24MC desktop high-speed refrigerated centrifuge (Hangzhou Shuolian Instrument Co., Ltd.).

[0027] 2) Test drug

[0028] Compound 1 can be prepared by existing methods, and can also be prepared by the following methods:

[0029] Put 35Kg of Moutan bark charcoal-dried medicinal material into the miniature multi-functional extraction tank twice, pour 8 times the amount of 95% ethanol into it, and extract it under vacuum and low temperature (60°C) for three times under reflux. The extraction time is 4h,...

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Abstract

The invention provides the use of the compound represented by formula 1 in the preparation of anticoagulant drugs. Experimental results show that the compound of the present invention can produce anticoagulant effect by affecting the endogenous blood coagulation system and inhibiting the activity of blood coagulation factors VIII, IX, XI and XII in plasma, and can also inhibit the formation of fibrin mediated by thrombin , has a good anticoagulant effect.

Description

technical field [0001] The invention relates to the application of a new natural product of moutan cortex charcoal in the preparation of anticoagulant medicine. Background technique [0002] Cortex Moutan, a traditional Chinese medicine, is the dried root bark of Paeonia surulicosa Andr., a plant in the Ranunculaceae family. Its nature and flavor are bitter, pungent, slightly cold. Guixin, Liver and Kidney meridians have the effects of clearing away heat and cooling blood, promoting blood circulation and removing blood stasis, and are used for blood entering the camp due to heat, hematemesis, bone steam without sweat, pain due to tumbling, carbuncle and sore. Moutan cortex charcoal is a processed product of Moutan cortex fried to burnt black with strong fire. It has the effect of cooling blood and stopping bleeding. )Wait. Modern pharmacological studies have shown that Danpi charcoal can shorten APTT, PRT, TT and PT in rats. It is believed that the mechanism by which Danp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/46A61K31/341A61P7/02
CPCC07B2200/07C07D307/46
Inventor 孟江黄绮韵杨小露王淑美
Owner 云浮市厚德中药饮片有限公司