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pH/temperature dual sensitive hydrogel preparation method

A double-sensitive, hydrogel technology, applied in the field of hydrogel, can solve the problems of little meaning and poor strength

Active Publication Date: 2020-10-02
北京法玛星医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To synthesize stable and efficient pH / temperature dual-sensitive hydrogels, there are several problems to overcome: 1) NIPAAm self-polymerization products are cotton-like, water-absorbing, and poor in strength above the LCST; 2) NIPAAm polymers are near the LCST temperature shrinkage, which is of little significance in practical applications; 3) The dual sensitive properties of pH / temperature are stably integrated in a hydrogel

Method used

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  • pH/temperature dual sensitive hydrogel preparation method
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  • pH/temperature dual sensitive hydrogel preparation method

Examples

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Embodiment 1

[0028] (1) Preparation of P (MAA)

[0029] Monomer α-methacrylic acid (MAA) 20ml, initiator potassium persulfate (K 2 S 2 o 8 ) 0.2g, add 200ml distilled water. In a 250mL three-neck flask, place it in a constant temperature water bath at 50°C and raise the temperature while stirring, control a certain stirring rate (300r / min), pass N 2 After 15 min, react for 4 h. The product was washed alternately with distilled water and absolute ethanol to remove unreacted monomers and impurities, and finally separated with a Buchner funnel. The product was dried at 50°C to obtain a cross-linked P(MAA) sample, which was pulverized for use.

[0030] (2) Synthesis of P (MAA) / P (AM-NIPAAm)

[0031] 0.5g N-isopropylacrylamide (NIPAAm) and 1g acrylamide (AM), 0.02g potassium persulfate (K 2 S 2 o 8 ), 0.02g N , N′-methylenebisacrylamide (MBA) was dissolved in 20% distilled water, and 0.5g P(MAA) was added to the above solution. Mix well and dissolve for 24 hours, pass N 2 After 15 mi...

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Abstract

The invention relates to hydrogel and particularly relates to a preparation method of pH / temperature double-sensitive hydrogel. The preparation method of the pH / temperature double-sensitive hydrogel comprises the following steps: performing free radical polymerization reaction to generate P(MAA), and pulverizing the P(MAA) for later use; dissolving NIPAAM, AM, an initiating agent and a cross-linking agent in distilled water, and adding the P(MAA) powder into the solution; performing uniform mixing and standing the mixture, performing low-temperature dissolution for 24h, introducing N2 in a closed state, performing heating copolymerization reaction, taking out gel after the reaction is finished, and washing the gel with distilled water; and cutting the gel into small pieces, and performingfreeze drying for 24h to obtain products.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a pH / temperature dual sensitive hydrogel preparation method. Background technique [0002] Environmentally sensitive hydrogel, also known as intelligent hydrogel, is a cross-linked polymer with a three-dimensional network structure that contains hydrophilic groups in the main chain or branch chain and can absorb a large amount of water. When changing (such as temperature, electric field, pH value, light intensity, ion intensity, GSH and other physical or chemical factors), the physical form or chemical structure of the gel will change significantly. Many scientists have done a lot of research on smart hydrogels, and they have been applied in the fields of drug carriers, medical diagnosis, tissue materials, adsorption and separation, etc. pH- and temperature-sensitive hydrogels are the most widely used. [0003] pH-sensitive hydrogels. The hydrogel responds accordingly to the swelling degree of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F220/56C08F220/54C08L33/26C08L33/02
CPCC08F220/56C08J3/075C08J2333/26C08J2433/02C08L33/26C08F220/54C08L33/02
Inventor 蒋山泉
Owner 北京法玛星医药科技有限公司