Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nicotine-gentisate complex crystal, method for preparing same and tobacco product with nicotine-gentisate complex crystal

A technology of gentisate and tobacco products, which is applied in the fields of tobacco, processed tobacco, and smoker's products, and can solve problems such as physical discomfort, gastrointestinal or respiratory tract irritation, and excessively fast and violent nicotine release.

Active Publication Date: 2018-07-27
CHINA TOBACCO YUNNAN IND
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These new tobacco products either use tobacco as the direct raw material or add nicotine directly, which will cause the nicotine to be released too fast and too violently when the product is consumed. Or respiratory irritation, causing physical discomfort

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nicotine-gentisate complex crystal, method for preparing same and tobacco product with nicotine-gentisate complex crystal
  • Nicotine-gentisate complex crystal, method for preparing same and tobacco product with nicotine-gentisate complex crystal
  • Nicotine-gentisate complex crystal, method for preparing same and tobacco product with nicotine-gentisate complex crystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Preparation of nicotine-gentisate complex crystals

[0040] 1.1 Preparation of nicotine and gentisic acid complex

[0041] Take 0.95g of gentisic acid in a conical flask, add 5mL of ethanol to dissolve it completely, then add 15mL of distilled water, stir until the mixture is uniform, and place the conical flask in a constant temperature stirrer after fully stirring Add 1.01 g of nicotine dropwise, control the reaction temperature to 35° C., complete the dropwise addition in 30 minutes, control the pH of the solution to 5.5, and stir until the reaction is completed.

[0042] 1.2 Complex single crystal culture

[0043] Filter the solution obtained after the reaction in step 1.1, place the filtrate in a dark place at room temperature, let it stand for 24 hours, then transfer the solution to a vacuum drying oven, and carry out vacuum drying treatment at a temperature of 35°C and a vacuum degree of 0.8MPa. A brownish-yellow viscous liquid was obtained after one week. ...

Embodiment 2

[0070] 1. Preparation of nicotine-gentisate complex crystal gum-based chewing tobacco

[0071] a. Take 30% gelatin, 55% sucralose, 1% propylene glycol, 1% glycerin, 1% coffee flavor, 2% Yunnan olive extract flavor, 1% mint flavor, 3% curcumin, 1% sodium bicarbonate %, nicotine-gentisate complex 5%;

[0072] b. Baking the gum base first, mixing the materials evenly, stirring at 60°C for 60 minutes, forming, extruding, roller rolling, cutting, aging, and subpackaging is the finished product.

[0073] 2. Nicotine dissolution test in vitro

[0074]The product prepared in step 1, the gum-based chewing tobacco containing pure nicotine, and the gum-based chewing tobacco containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

[0075] The present invention utilizes an oral cavity simulated chewing instrument to perform in vitro dissolution tests of nicotine on the above three gum-based chewing tobacco products.

[0076] Test method: Add the ar...

Embodiment 3

[0084] 1. Preparation of pouched snus containing nicotine-gentisate complex crystals

[0085] a. Take 50% of microcrystalline cellulose, 10% of peppermint essence, 5% of propylene glycol, and 10% of nicotine-gentisate complex crystals;

[0086] b. After mixing and sieving the materials, take 20-mesh powder and mix evenly. After baking and heat treatment in a pasteurizer, add water 14%, sodium chloride 3%, sodium carbonate 2%, vitamin C1 %, evenly blended, refrigerated for 12 hours, sprayed with 2% honey, 1% glucose, 1% aspartame, and 1% sodium carbonate, sealed and refrigerated for 24 hours, sterilized by ultraviolet light for 3 hours, and then packaged to obtain the finished product.

[0087] 2. Nicotine dissolution test in vitro

[0088] The product prepared in step 1, the bagged snus containing pure nicotine, and the bagged snus containing shredded tobacco were respectively subjected to nicotine dissolution test in vitro.

[0089] The present invention utilizes an oral ca...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Crystal densityaaaaaaaaaa
Densityaaaaaaaaaa
Resonance frequencyaaaaaaaaaa
Login to View More

Abstract

The invention discloses a nicotine-gentisate complex crystal. A molecular formula of the nicotine-gentisate complex crystal is C7H6O4 C10H16N2; the nicotine-gentisate complex crystal belongs to monoclinic crystal systems and is provided with space groups P21, unit cell parameters alpha and gamma are 90.00 degrees, and a unit cell parameter beta is equal to 112.40 degrees. The invention further discloses a method for preparing the nicotine-gentisate complex crystal and a tobacco product with the nicotine-gentisate complex crystal. The method includes a, placing gentisic acid in a conical flask,adding solvents into the conical flask, further adding distilled water into the conical flask and stirring the gentisic acid, the solvents and the distilled water until the gentisic acid, the solvents and the distilled water are uniformly mixed with one another; b, carrying out light-resistant treatment on the conical flask obtained at the step a, dropwise adding nicotine under a stirring condition and controlling the reaction temperature and the pH (potential of hydrogen); c, filtering solution obtained after reaction is carried out at the step b, allowing the solution to stand still at normal-temperature light-resistant locations and drying the solution to obtain brown viscous liquid; d, placing the brown viscous liquid obtained at the step c at normal-temperature light-resistant locations and allowing crystals to grow so as to obtain brown transparent needle-shaped solid. The tobacco product can be a gum-based chewing tobacco, a mouth tobacco in bags, electronic cigarette liquid ora heating incombustible cigarette.

Description

technical field [0001] The invention belongs to the technical field of organic crystals, and in particular relates to a nicotine-gentisate complex crystal, a preparation method thereof and a tobacco product containing the same. Background technique [0002] Nicotine is the main chemical component of natural alkaloids in tobacco leaves. The molecular structure is composed of two nitrogen heterocycles, the pyrrole ring pKa=7.87, and the pyridine ring pKa=3.15. Due to the influence of aromatization, the nitrogen atom in the pyridine ring has a weak basicity, which is similar to that of aromatic amines. The nitrogen atom in the pyrrolidine ring belongs to a tertiary amine. Since the ring is not aromatic, its basicity is similar to that of an aliphatic tertiary amine, so nicotine is easy to chemically react with an acid. Rose, J.E., et al., Pulmonary delivery of nicotine pyruvate: Sensory and pharmacokinetic characteristics. Experimental and Clinical Psychopharmacology, 2010.18(...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A24B15/16A24B15/18A24B13/00A24F47/00
CPCA24F47/008A24B13/00A24B15/16A24B15/18
Inventor 杨继杨柳赵伟段沅杏赵杨巩效伟韩熠洪鎏李寿波雷萍李廷华陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com