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A kind of benzalkonium chloride topical solution and preparation method thereof

A benzalkonium chloride and solution technology, applied in the field of benzalkonium chloride topical solution and preparation thereof, can solve the problems of insufficient absorption, poor antibacterial effect, skin irritation and the like, and achieves improvement of insufficient absorption and unstable antibacterial effect. , improve the absorption effect

Active Publication Date: 2020-04-10
HAINAN HUALON PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to: overcome the problems of insufficient absorption, easy irritation to the skin, poor antibacterial effect and the like in the existing common benzalkonium chloride preparations, and provide a product with high skin absorption, low irritation, and good antibacterial stability. Benzalkonium chloride topical solution and preparation method thereof

Method used

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  • A kind of benzalkonium chloride topical solution and preparation method thereof
  • A kind of benzalkonium chloride topical solution and preparation method thereof
  • A kind of benzalkonium chloride topical solution and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Eight groups of benzalkonium chloride topical solutions were prepared, and the dosage of each component was as follows. According to the components and dosage of A-H group below, add benzalkonium chloride to the pH buffer solution and stir to dissolve, then add coolant and penetration enhancer in turn, stir to dissolve, and finally add viscosity enhancer and stir until it becomes clear Solution, stand still, that is.

[0027] Table 1 Eight groups of benzalkonium chloride topical solutions

[0028]

[0029]

Embodiment 2

[0030] Embodiment 2 antibacterial effect evaluation

[0031] In this example, the antibacterial effect of the external application solution of benzalkonium chloride obtained in the example of the present invention was determined by the disc agar diffusion method.

[0032] 1. Prepare antibacterial tablets: take a dry sterile filter paper with a diameter of 9 cm, drop 0.5ml of benzalkonium chloride topical solution-3 in the center of the filter paper, place the filter paper in a clean sterile plate, and dry it naturally at room temperature for backup Use; make at least 9 such antibacterial tablets as samples. Take a dry sterile filter paper sheet for the negative control photo, add 0.5ml sterilized water dropwise to the center of the filter paper sheet, and dry it for later use; make at least 3 antibacterial sheets in this way.

[0033] 2. Prepare the stained plate: three kinds of bacteria, including Gram-positive bacteria representative (Staphylococcus aureus) and two Gram-neg...

Embodiment 3

[0040] Embodiment 3 clinical effect evaluation

[0041] 1. General information

[0042] gender 70 males and 74 females, a total of 144 cases age 1-10 years old: 33 cases; 11-20 years old: 38 cases; 21-30 years old: 36 cases; 31-40 years old: 37 cases cases 49 cases of subcutaneous abscess of extremities; 45 cases of surgical incision infection; 50 cases of trauma infection

[0043] 2. Treatment method: clean up the wound surface, randomly assign and set up 9 groups of patients, 16 patients in each group, use the benzalkonium chloride solution of groups A-H in Example 1 to clean the affected parts of the eight groups, and the other group of patients to use domestic marketed benzalkonium chloride solution Ordinary benzalkonium chloride lotion was used as a control. After cleaning, change the dressing and wrap it carefully with sterile gauze. Such treatment was carried out twice a day, and the therapeutic effect was evaluated for 7 days.

[0044] 3. ...

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Abstract

The invention discloses a benzalkonium chloride external solution and a preparation method thereof. The benzalkonium chloride external solution comprises the following components in percentage by mass: 0.06 to 0.12 percent of benzalkonium chloride, 2.0 to 6.5 percent of a permeation enhancer, 0.5 to 2.0 percent of a tackifier, 0.1 to 6.0 percent of a cooling agent and the balance of a pH buffer solution. The benzalkonium chloride external solution can effectively improve absorption of the benzalkonium chloride effective component on an affected part, completely guarantees the antibacterial effect of the benzalkonium chloride, avoids organ toxicity and skin allergic reaction caused by the benzalkonium chloride and improves the problems that the traditional benzalkonium chloride external preparation is insufficient to absorb and has an unstable antibacterial effect; furthermore, the preparation method is simple, the benzalkonium chloride external solution can be produced without specialequipment, and a good application prospect is achieved.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically relates to a benzalkonium chloride external solution with high skin absorption, low irritation and good antibacterial stability and a preparation method thereof. Background technique [0002] Benzalkonium chloride is a kind of cationic surfactant, which is a non-oxidizing fungicide. It has broad-spectrum and high-efficiency sterilization and algae killing ability, can effectively control the reproduction of bacteria and algae and the growth of slime in water, and has good slime stripping It has a certain dispersion and penetration effect, and also has a certain degreasing, deodorizing ability and corrosion inhibition effect. This product is easily soluble in water or ethanol, slightly soluble in ether, and belongs to the class of disinfectant and antiseptic drugs. Benzalkonium chloride dissociates into cationic active groups in aqueous solution, which has cleaning and bactericidal e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/14A61K47/38A61P31/04
CPCA61K9/0014A61K9/08A61K31/14A61K47/38A61P31/04
Inventor 陈雪君吴淑铭
Owner HAINAN HUALON PHARM
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