Transwell cell culture device capable of simulating stress effects on vascular walls

Abstract

The invention provides a transwell cell culture device capable of simulating stress effects on vascular walls and belongs to a medical experiment device. The device comprises multiple culture dish holes, a cavity arranged inside and used for liquid circulation, multiple water inlets communicated with the cavity and multiple water outlets communicated with the cavity, wherein the bottoms of the culture dish holes are communicated with the cavity. The transwell cell culture device capable of simulating vascular wall stress effects at least comprises a bent part with an L-shaped section, a straight part with an I-shaped section and a T-shaped part with a T-shaped section; one culture dish hole is correspondingly formed in each of the bent part, the straight part and the T-shaped part; the part, located at the bent part, of the cavity is in the L shape consistent with the bent part; the part, located at the straight part, of the cavity is in an I shape consistent with the straight part; the part, located at the T-shaped part, of the cavity is in the T shape consistent with the T-shaped part. The device can quickly and conveniently simulate the stress effects on the vascular walls, so that researchers can compare and observe the cell condition of a co-culture system under different stress effects on the vascular walls.

Description

technical field [0001] The invention relates to a medical experiment device, in particular to a transwell cell culture device for simulating the force acting on a blood vessel wall. Background technique [0002] The co-culture system is to establish a culture system similar to the in vivo environment, and make the in vitro environment as consistent as possible with the in vivo environment, so that cells can communicate with each other and support each other for reproduction. [0003] In the existing co-culture technology, the combination of transwell chamber and culture plate is usually used to establish a co-culture system to conduct research on co-culture, cell chemotaxis, cell migration, and cell invasion. [0004] The culture plate in the prior art has a single structure and cannot simulate the cell conditions in the co-culture model under the force of the blood vessel wall, resulting in a large difference between the experimental results and the real results. Contents...

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Problems solved by technology

[0005] In view of the above existing problems, the present invention provides a transwell cell culture device that simulates the stress on the blood vessel wall to solve the problem that the culture plate in the prior art cannot simulate the stress on the blood vessel wall, and can quickly and easily simulate bleeding The stress on the vessel wall is convenient for researchers to compare and observe the cells in the co-culture system under different forces on the vessel wall, filling the gap in this field at home and abroad

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