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Novel pharmaceutical use of neohesperidin

A technology for the use of neohesperidin, which is applied in the field of neohesperidin production, can solve problems such as no new uses of neohesperidin, and achieve the treatment or relief of bronchial asthma, elimination or relief of loss of appetite, and low toxicity. Effect

Inactive Publication Date: 2018-09-04
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no new use of neohesperidin in the preparation of medicines for treating or alleviating bronchial asthma

Method used

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  • Novel pharmaceutical use of neohesperidin
  • Novel pharmaceutical use of neohesperidin
  • Novel pharmaceutical use of neohesperidin

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Experimental program
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Embodiment Construction

[0017] In order to make those skilled in the art clearly understand the technical solutions and advantages of the present invention, the present invention will be further described in detail in combination with animal experiments below, but it is not intended to limit the protection scope of the present invention.

[0018] 1. Materials and methods

[0019] 1.1 Experimental animals

[0020] BALB / c mice, female, weighing 20-25g, selected 50 healthy mice, divided them into 5 groups by random grouping method, 10 mice in each group, set up a blank control group, a model control group, and a positive drug control group (dexamethasone Sodium phosphate injection, concentration is 0.25mg / mL), low concentration administration group (neohesperidin solution, concentration is 25mg / mL), high concentration administration group (neohesperidin solution, concentration is 50mg / mL) .

[0021] 1.2 Sample handling

[0022] After feeding the mice for one week to adapt to the growth environment, t...

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PUM

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Abstract

The invention discloses a novel pharmaceutical use of neohesperidin and particularly discloses a use of neohesperidin in the preparation of a drug for treating or alleviating bronchial asthma, or in the preparation of a product for eliminating or alleviating loss of appetite due to bronchial asthma, or in the preparation of a drug for treating diseases caused by Th1 / Th2 cell immune imbalance. Theinvention provides a new approach to neohesperidin application.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new pharmaceutical application of neohesperidin, in particular to the production of neohesperidin [0002] Prepare the purposes in the medicine of treating or alleviating bronchial asthma. Background technique [0003] Neohesperidin is a dihydroflavonoid glycoside compound, which is a secondary metabolite of citrus plants in the Rutaceae family, and is widely distributed in a variety of plants. Studies have shown that neohesperidin has strong biological activities in promoting gastric motility, lowering blood fat, lowering blood sugar, and promoting skin microcirculation. Chinese Patent No.: CN 1836665 B discloses an invention patent titled "Pharmaceutical Use of Neohesperidin or its Composition", which provides the use of Neohesperidin or its composition in the preparation of drugs for promoting gastric motility. Chinese Patent No.: CN 1317938 A discloses an invention patent titled "A ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/06
CPCA61K31/7048A61P11/06
Inventor 时晓磊杨艳萍
Owner JILIN UNIV