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Application of CLEC-2 (C-Type Lectin Receptor-2) in preparing medicine for treating craniocerebral injury

A kind of craniocerebral injury and drug technology, applied in the field of biomedicine, can solve the problem that the effect of craniocerebral injury is not reported, etc.

Active Publication Date: 2018-09-04
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its role in traumatic brain injury has not been reported

Method used

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  • Application of CLEC-2 (C-Type Lectin Receptor-2) in preparing medicine for treating craniocerebral injury
  • Application of CLEC-2 (C-Type Lectin Receptor-2) in preparing medicine for treating craniocerebral injury
  • Application of CLEC-2 (C-Type Lectin Receptor-2) in preparing medicine for treating craniocerebral injury

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Twenty-four 6-week-old ICR mice with basically the same body weight were randomly divided into four groups, 6 in each group, namely: simple control group (Sham group), simple craniocerebral injury group (TBI group), craniocerebral injury pretreatment group (Pre group) and craniocerebral injury post-treatment group (Post group).

[0064] The modeling steps of craniocerebral injury are as follows: the mice in each group were fixed with a stereotaxic instrument, the mouse scalp was cut to expose the skull, and the coronal suture and sagittal suture were divided into two sides, and a 4mm diameter hole was drilled in the left hemisphere. A small circular hole exposes the brain tissue, and then hits it with a free-fall striker to establish a craniocerebral injury model. The mice in the Sham group did not perform any operations before and after craniocerebral injury, and the mice in the Pre group were given 400 ng of platelet CLEC-2 by intracerebroventricular injection 30 minu...

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Abstract

The invention discloses the application of CLEC-2 (C-Type Lectin Receptor-2) in preparing a medicine for treating craniocerebral injury and further discloses a medicine for treating craniocerebral injury. The method comprises a C-type lectin receptor-2 and pharmaceutically acceptable auxiliary materials. The invention discloses thrombocyte CLEC-2 which has a function of treating craniocerebral injury such as cerebral trauma and potential clinical values, and provides novel ideas and technical supports for clinical treatment on patients suffering from craniocerebral injury.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of CLEC-2 in the preparation of medicine for treating craniocerebral injury. Background technique [0002] At present, craniocerebral injury is very common clinically, such as traumatic brain injury, which has a high mortality and disability rate, and is especially common in young people, causing a great burden to the society. Changes in the condition after traumatic brain injury are rapid and complex, and last for a long time. Although the drugs and surgical operations for craniocerebral injury are improving day by day, effective treatment methods and means are quite scarce, especially the lack of drug therapy. Therefore, it is imperative to fully study the pathological changes after craniocerebral injury in order to seek better treatments. [0003] Taking traumatic brain injury as an example, its pathogenesis is mainly divided into two types, one is physical damage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P29/00A61P25/00
CPCA61K38/178A61P25/00A61P29/00
Inventor 陶陆阳高诚陈溪萍王浩晨刘司南陶泓旭
Owner SUZHOU UNIV