A kind of preparation method of high-purity chlorinated 2-carboxybenzophenone
A technology of methyl benzophenone and benzophenone is applied in the preparation of carboxylates, carbon-based compounds, preparation of organic compounds, etc., and achieves the effects of low cost, environmentally friendly process, and simple synthesis steps
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[0027] The preparation method reaction scheme of the present invention is as follows:
[0028]
[0029] Take 2-chloro-6-(2-chlorobenzoyl)benzoic acid (compound A) and 6-(2-chlorobenzoyl)benzoic acid (compound B) as an example to illustrate the technical scheme of the present invention,
[0030]
Embodiment 1
[0031] The preparation of embodiment 1 compound B (6-(2-chlorobenzoyl) benzoic acid)
[0032] (1) Preparation of Grignard Reagents
[0033]
[0034] Get 48 grams (2.0M) of magnesium powder, put into four-neck round bottom flask, pass into dry hot nitrogen, cool after 30 minutes. Add o-methyl chlorobenzene, a small amount of ether and iodine, and heat to initiate the reaction. Diethyl ether was added dropwise to the reaction bottle to make the total solvent volume 1000 ml, the reaction temperature was controlled, the reaction was carried out for 4 hours, cooled, and the obtained Grignard reagent was used for future use.
[0035] (2) Preparation of intermediate 6-(2-chlorobenzoyl)toluene
[0036]
[0037] Add 1000 ml of ether solution (concentration 2.0M) of Grignard reagent into the xylene solution containing 420.0 g (2.4M) o-chlorobenzoyl chloride slowly under ice-bath conditions, and continue the reflux reaction for 36 hours. After the reaction is completed, depressur...
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