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Integrated micro-fluidic neural network chip and bionic implementation method

A neural network and chip technology, which is applied in the field of integrated microfluidic neural network chips and bionic implementation, can solve the problems of inability to complete the time and space, precise control operation and analysis research of the in-chip brain bionic neural network.

Active Publication Date: 2018-09-14
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various neurochip systems based on microfluidic chip technology are mostly single-pipeline or double-pipeline chip structures, which can only carry out small-scale nerve cell culture and neurovascular interface related research, but cannot complete the brain-in-chip bionic neural system. Research on time and space precise controllable operation and analysis of network

Method used

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  • Integrated micro-fluidic neural network chip and bionic implementation method
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Such as figure 1 As shown, an integrated microfluidic neural network chip provided in Embodiment 1 of the present invention includes a flow layer and a control layer, wherein the flow layer includes a microcavity array, 1 connecting pipeline network, and 2 groups of transmission pipeline networks (5 and 6 ), 2 entrances and 2 exits. The microcavity array includes 8 groups of microcavities, each group of microcavities is provided with 4 columns of microcavities (11), and each column of microcavities is provided with more than 25 microcavities (13). The pipelines (14) connecting the pipeline network communicate with adjacent microcavities (13), and the four microcavities (13) located at four adjacent corners communicate with each other through the pipelines (14) in the connecting pipeline network. Two sets of transmission pipeline networks (5 and 6) are respectively located at the upper and lower ends of the microcavity array and communicate with the microcavity array. E...

Embodiment 2

[0062] Based on the integrated microfluidic neural network chip of Example 1, the present invention provides a biomimetic implementation method using the above chip, wherein the cell samples are mammalian-derived neural cells and neural stem cells. The process of realizing the localized inoculation of nerve cells is as follows:

[0063] S1: Apply external air pressure (25-35psi) to the intake inlets (7 and 8) connected to the transmission microvalves on the two inlet and outlet transmission pipelines, so that the transmission microvalves (231 and 232) on the two inlet and outlet transmission pipelines Open and close 7 groups of microvalves (241, 242, 243, 244, 245, 246 and 247) and 6 multi-transport microvalve groups (233, 234, 235, 236, 237 and 238) connected to the microcavity transmission pipeline, No external air pressure is applied to its corresponding air inlet.

[0064] make such figure 2 In the flow layer, the auxiliary inlet (212) and auxiliary outlet (221) are clo...

Embodiment 3

[0073] Further, the execution process of nerve growth factor treatment for nerve cells and neural networks in a single group of microcavities is as follows:

[0074] First, if Image 6 As shown, two single-transmission microvalve groups (231 and 232) will be opened, the corresponding transmission microvalves (233, 236 and 237) on the microcavity transmission pipelines that are communicated with the single group of microcavities to be closed will be closed, and other individual microvalves (233, 236 and 237) will be opened. Multi-transport microvalve groups (434, 435 and 438), open corresponding 2 groups of connecting microvalves (642 and 643) on the connecting pipes connected on both sides of the single group of microcavities to be processed, and close other groups of connecting microvalves (241 , 244, 245, 246 and 247).

[0075] Make the auxiliary inlet (232) and the auxiliary outlet (231) in the fluidized layer close, the biochemical stimulant inlet (611) and the biochemica...

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Abstract

The invention discloses an integrated micro-fluidic neural network chip and a bionic implementation method. A flow layer of the chip is provided with a micro-cavity array, a connecting pipeline network, two groups of transmission pipeline networks and an inlet / outlet; the two groups of transmission pipeline networks are respectively positioned at the upper and lower ends of the micro-cavity arrayand communicated with the micro-cavity array; a control layer comprises a transmission valve, a connecting valve, an air inlet pipeline and an air inlet; the connecting valve is arranged just under the connecting pipeline between two adjacent groups of micro-cavities; the transmission valves corresponding to the two inlet / outlet transmission pipelines are respectively positioned on the outlet sideand the inlet side; between two optional groups of micro-cavities, at least one transmission valve exists in the transmission valves on each micro-cavity transmission pipeline communicated with any one group of micro-cavities, and all the transmission valves on the micro-cavity transmission pipeline of the other group of micro-cavities are not communicated with the same air inlet. Based on the chip of the structure, functions of arrayed cell localization and inoculation, bionic neural network building, biochemical stimulus treatment of nerve cells and neural network in a single group of micro-cavity areas and sample recovery can be realized.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, and in particular relates to an integrated microfluidic neural network chip and a bionic realization method. Background technique [0002] As the center of the nervous system, the brain is the most complex organ in vertebrates. In-depth research on brain nerves is a key prerequisite for revealing the mysteries of the brain, understanding the functions and mechanisms of nerve-related cells in physiological and pathological environments, and then rationally conducting neuroclinical treatments. Nerve cell activity is a real-time dynamic life process, including physiological processes such as the regulation of body functions based on neural networks, and pathological processes such as nerve damage induced by brain diseases. The conventional in vivo research mode directly uses the animal body as the research object, which can obtain more authentic and reliable experimental information that...

Claims

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Application Information

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IPC IPC(8): G06N3/063G06N3/06
CPCG06N3/061G06N3/063
Inventor 刘文明
Owner CENT SOUTH UNIV
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