Compound salicylic acid lotion for treating keratinized tinea pedis and preparation method thereof

A technology of salicylic acid lotion and tinea pedis, which is applied in the field of medicine, can solve the problems of poor transdermal absorption and poor curative effect, and achieve the effects of improving bioavailability, helping skin tissue repair, and increasing resistance

Pending Publication Date: 2018-10-02
廖树高
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems in the prior art that the keratotic tinea pedis is difficult to prevent and treat, the curative effect of most unilateral agents is not good, and the transdermal absorption effect of some compound preparations is poor, the present invention aims to provide an antifungal, antifungal and antifungal agent. Compound salicylic acid lotion for treating keratotic tinea pedis and its preparation method with itching and exfoliating effect, no skin irritation, stable drug effect, convenient use and simple preparation process

Method used

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  • Compound salicylic acid lotion for treating keratinized tinea pedis and preparation method thereof
  • Compound salicylic acid lotion for treating keratinized tinea pedis and preparation method thereof
  • Compound salicylic acid lotion for treating keratinized tinea pedis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0030] Embodiment 1-3: Preparation of Centella asiatica extract.

[0031] Table 1. Process parameters and content results of the preparation process of Centella asiatica extract

[0032]

[0033] Prepare the Centella asiatica extract according to the processing parameters in Table 1, and the specific process is as follows:

[0034] a) sieving the dried centella asiatica powder after crushing to obtain centella asiatica powder;

[0035] b) Extract the Centella asiatica powder obtained in step a) with ethanol aqueous solution for 3 times, each extraction time is the same, and filter after extraction to obtain the filtrate;

[0036] c) adding activated alumina and activated carbon to the filtrate obtained in step b), heating and stirring until the color of the liquid disappears and then filtering to obtain a decolorized filtrate;

[0037] d) concentrating the decolorized filtrate obtained in step c) under reduced pressure to obtain Centella asiatica extract.

[0038] Accord...

Embodiment 4-6

[0039] Embodiment 4-6: the preparation of compound salicylic acid lotion.

[0040] Table 2. Components and dosage of compound salicylic acid lotion

[0041]

[0042]

[0043] Prepare compound salicylic acid lotion according to the formula in table 2, and concrete process is as follows:

[0044] 1) Prepare acid solution: weigh salicylic acid, benzoic acid and ethanol, and dissolve salicylic acid and benzoic acid in ethanol to obtain acid solution;

[0045] 2) Prepare phenol solution: weigh resorcinol, phenol and penetration enhancer, and dissolve resorcinol and phenol in the penetration enhancer to obtain phenol solution;

[0046] 3) Using a magnetic stirring device, first mix the acid solution obtained in step 1) and the phenol solution obtained in step 2) uniformly, and then add an appropriate amount of pure water, pre-weighed stabilizer and centella asiatica extract Liquid, after stopping stirring, add water constant volume, obtain the compound salicylic acid lotion th...

experiment example 1

[0047] Experimental Example 1: Skin irritation test of compound salicylic acid lotion.

[0048] Adopt the compound salicylic acid lotion obtained in embodiment 4-6 to carry out skin irritation test.

[0049] The specific experimental process is as follows: select a rabbit with a body weight of 2.0-2.5 kg as the experimental animal, and 24 hours before the test, use scissors and an electric shaver to shave an area on each side of the rabbit's back spine, with a size of about 10 cm × 5 cm. Among them, the upper part is the intact skin test area, the lower part is the damaged skin test area, and the test drug or positive control substance is applied on the left side (product name: compound salicylic acid tincture, batch number: 151101, manufacturer: Jiangsu Lingbao Pharmaceutical Co., Ltd. Co., Ltd.), the application amount is 1mL, and the right side is the blank control; the skin on the left and right sides of the damaged skin test area is cut with a scalpel before administratio...

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Abstract

The invention belongs to the technical field of medicine, and relates to a compound salicylic acid lotion for treating keratinized tinea pedis and a preparation method thereof. Specifically, the compound salicylic acid lotion is prepared from salicylic acid, benzoic acid, resorcinol, phenol, a stabilizing agent, a herba centellae extracting solution, a penetration enhancer, ethanol and water. According to the compound salicylic acid lotion disclosed by the invention, by selecting a proper dosage form and a Chinese and western medicine combination formula, tinea can be better removed, and meanwhile, the effects of killing and inhibiting bacteria, diminishing inflammation and relieving itching as well as astringing sores and promoting tissue regeneration can be expressed; for skin lesion inhyperkeratosis, pachynsis or more scales, a compound lotion soaking way is adopted, not only can keratin be softened by utilizing a softening function of medicine in the compound salicylic acid lotion, but also growth of fungi can be inhibited by utilizing an antibacterial function of the medicine, so that a treatment purpose can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound salicylic acid lotion for treating keratotic tinea pedis and a preparation method thereof. Background technique [0002] Tinea manus and pedis is a kind of common dermatophytosis, mainly occurs in palm, sole or finger (toe) crevice, and its pathogenic bacteria mainly include Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton etc. The disease is widespread all over the world, and the incidence rate in the south of my country is higher than that in the north. There are four common clinical types of the disease: (1) Dipping type: the skin between the fingers (toes) is whitish, eroded, and soaked, with clear edges, and moist bright red newborn skin is left after the soaked epidermis is removed; ( 2) Vesicular type: blisters appear on the soles of the feet or palms, and even several small blisters merge into larger blisters with clear boundaries, no red ski...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P17/00A61P31/10A61K31/60A61K31/192A61K31/05
CPCA61K31/05A61K31/192A61K31/60A61K36/23A61K2300/00
Inventor 王有志浦洁陈旭升王德才
Owner 廖树高
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