Preparation method of traditional Chinese medicine and western medicine composition for treating chronic gastric ulcer

A technology for chronic gastric ulcers and Chinese and Western medicines, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as secondary injury

Inactive Publication Date: 2018-10-16
HEFEI HUAGAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent literature (publication number: CN108078951A) discloses a kind of cimetidine composition that is used for the treatment of gastric disease, comprises the raw material of following weight part: 42-46 parts of cimetidine, 10-14 parts of compatibilizer, moisturizing 6-8 parts of wet agent, 11-13 parts of disintegrant, 6-10 parts of lubricant, 1-3 parts of flavoring agent, and 12-18 parts of solvent. , causing secondary damage

Method used

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  • Preparation method of traditional Chinese medicine and western medicine composition for treating chronic gastric ulcer
  • Preparation method of traditional Chinese medicine and western medicine composition for treating chronic gastric ulcer
  • Preparation method of traditional Chinese medicine and western medicine composition for treating chronic gastric ulcer

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Embodiment 1

[0028] A kind of preparation method of Chinese and western medicine composition for the treatment of chronic gastric ulcer of the present embodiment, comprises the following steps:

[0029] Step 1: get cimetidine and add the mixed solution of acetonitrile / water, stir and dissolve, the stirring speed is 6r / min, and the stirring time is 8min, then sequentially add solubilizing agent, leaching auxiliary agent wherein, continue to stir 12min, then add to Add Desmodium doped with Astragalus extract and propolis, continue to stir for 4 minutes, and then carry out suction filtration;

[0030] Step 2: Lower the filtrate in step 1 to 5°C, slowly add 0.2% n-butyl ether in the total amount of the filtrate dropwise, continue to cool down and crystallize, heat and stir until the crystallization is complete, grow crystals, filter with suction, wash with water, and dry to obtain white Crystalline powder.

[0031] The mass ratio of cimetidine and Desmodium doped with Astragalus extract in th...

Embodiment 2

[0040] A kind of preparation method of Chinese and western medicine composition for the treatment of chronic gastric ulcer of the present embodiment, comprises the following steps:

[0041] Step 1: get cimetidine and add the mixed solution of acetonitrile / water, stir and dissolve, the stirring speed is 10r / min, and the stirring time is 14min, then sequentially add solubilizing agent, leaching auxiliary agent wherein, continue to stir 16min, then add to Add Desmodium doped with Astragalus extract and propolis, continue to stir for 10 minutes, and then carry out suction filtration;

[0042] Step 2: Lower the filtrate in step 1 to 5°C, slowly add 0.6% n-butyl ether of the total amount of the filtrate dropwise, continue to cool down and crystallize, heat and stir until the crystallization is complete, grow crystals, filter with suction, wash with water, and dry to obtain white Crystalline powder.

[0043] The mass ratio of cimetidine and Desmodium doped with Astragalus extract in...

Embodiment 3

[0052] A kind of preparation method of Chinese and western medicine composition for the treatment of chronic gastric ulcer of the present embodiment, comprises the following steps:

[0053] Step 1: get cimetidine and add the mixed solution of acetonitrile / water, stir and dissolve, the stirring speed is 8r / min, and the stirring time is 11min, then sequentially add solubilizing agent, leaching auxiliary agent wherein, continue to stir for 14min, then add to Add Desmodium doped with Astragalus extract and propolis, continue to stir for 7 minutes, and then carry out suction filtration;

[0054] Step 2: Lower the filtrate in step 1 to 5°C, slowly add 0.4% n-butyl ether in the total amount of the filtrate dropwise, continue to cool down and crystallize, heat and stir until the crystallization is complete, grow crystals, filter with suction, wash with water, and dry to obtain white Crystalline powder.

[0055] The mass ratio of cimetidine and Desmodium doped with Astragalus extract ...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine and western medicine composition for treating the chronic gastric ulcer. The method comprises the following step that 1,cimetidine is taken and added into a mixed solution of acetonitrile / water, stirring is conducted for dissolution under the conditions that the stirring rotating speed is 6-10 r / min and stirring time is 8-14 min, then a solubilizing agent and a leaching auxiliary agent are added into the mixture sequentially, stirring is continued for 12-16 min, then an extraction solution of herba lysimachiae doped with radix astragali seu hedysari and propolis are added into the mixture, stirring is continued for 4-10 min, and then suction filtration is conducted. The purpose of the invention is to provide the preparation method of the traditional Chinese medicine and western medicine composition for treating the chronic gastric ulcer, the composition can cure the chronic gastric ulcer, has the health care treatment effect at the same time, does not cause secondary damage to the intestines and stomach, and has high use values and good application prospects.

Description

technical field [0001] The invention relates to the technical field of chronic gastric ulcer treatment, in particular to a preparation method of a Chinese and Western medicine composition for treating chronic gastric ulcer. Background technique [0002] Chronic gastric ulcer is clinically characterized by intermittent and recurrent rhythmic epigastric pain, often accompanied by sensations such as heating, acid regurgitation, burning heat, and noise, and even nausea, vomiting, hematemesis, and blood in the stool. , Oval chronic ulcer, inflammation of superficial gastritis is limited to gastric pits and the surface layer of gastric mucosa, epithelial cell degeneration, pit epithelial hyperplasia and gastric mucosal lamina propria inflammatory cell infiltration, causing mucosal hyperemia, edema, exudation, multiple In the gastric antrum, sometimes there is a small amount of erosion and bleeding. Some patients have more erosive lesions in the gastric antrum, or with verrucous pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K36/481A61P1/04A61K31/4164A61K35/644
CPCA61K31/4164A61K35/644A61K36/185A61K36/481A61K36/53A61P1/04A61K2300/00
Inventor 张安育
Owner HEFEI HUAGAI BIOTECH CO LTD
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