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A biomimetic hollow silica composite particle modified by β-1,3-d-glucan and its application

A silicon dioxide and composite particle technology, applied in the field of vaccine adjuvants and drug carriers, can solve the problems of lack of biological activity on the surface, fast drug release speed, and low drug load, so as to improve the utilization rate of antigens, reduce toxic and side effects, The effect of low production cost

Active Publication Date: 2020-10-23
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although hollow silica particles prepared with bacteria as templates can be used as vaccine adjuvants and drug carriers to take advantage of their morphology, the unmodified hollow silica particles have relatively low drug loading and fast drug release. , and the surface lacks biological activity, these problems need to be solved urgently

Method used

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  • A biomimetic hollow silica composite particle modified by β-1,3-d-glucan and its application
  • A biomimetic hollow silica composite particle modified by β-1,3-d-glucan and its application
  • A biomimetic hollow silica composite particle modified by β-1,3-d-glucan and its application

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Embodiment 1

[0053] A biomimetic hollow silica composite particle modified by β-1,3-D-glucan, according to figure 1 The process shown is prepared, and the specific preparation process is as follows:

[0054] (1) Preparation of bacteria-based biomimetic hollow silica particles with nanotransport channels

[0055] Most bacteria can be used as soft templates for the preparation of hollow silica particles. In this example, two common bacteria (E. Biomimetic hollow silica particles.

[0056] Take 1.8mL of 8×10 10 Individual / mL Escherichia coli or Staphylococcus aureus aqueous solution to the flask, then add 5mL of 25% ammonia water, then add 73.2mL absolute ethanol, ultrasonically mix for 10min; under magnetic stirring, add 2.23mL orthosilicic acid drop by drop The mixture of ethyl ester and 17.77mL ethanol solution was reacted at room temperature for 72h; after the reaction was completed, the obtained particles were collected by centrifugation at 4000rpm for 10min, and the obtained particle...

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Abstract

The invention discloses beta-1,3-D-glucan modified biomimetic hollow silicon dioxide composite particles and application thereof. The composite particles are obtained by performing a coupling reactionon biomimetic hollow silicon dioxide particles and beta-1,3-D-glucan, wherein the pore diameter range of nanometer transmission pore passages of the biomimetic hollow silicon dioxide particles is 1.7-15.2nm. The composite particles have the morphologies of bacteria and the nanometer transmission pore passages with appropriate pore diameter distribution, facilitate passing of antigens and medicines with different molecular weights, have relatively high antigen loading capacity, can continuously release the antigens, can increase the antigen utilization rate, reduce the number of injections andreduce toxic and side effects of the antigens and vaccine adjuvants, and continuously provides an immunoprotective effect; the composite particles have the equivalent level of inducing antigen-specific antibodies to an aluminum adjuvant and a Freund's adjuvant, and have a wide application prospect in the biomedical field; in addition, the composite particles is simple in preparation method, low in cost, environment-friendly and low in preparation cost, and have an industrial production potential.

Description

technical field [0001] The invention relates to the field of vaccine adjuvants and drug carriers, and more specifically, to a biomimetic hollow silica composite particle modified by β-1,3-D-glucan and its application. Background technique [0002] Porous silica particle material has the advantages of high specific surface area and pore volume, good physical and chemical stability, low toxicity and good biocompatibility, rich in silanol on the surface, easy to functionalize, and low cost. It is widely used in medical bioengineering fields such as vaccine antigen carrier, drug carrier, gene carrier, and bioimaging. In particular, the chemical stability of the porous silica particle material can protect the active drug loaded in it from the damage of the in vivo environment, and the porous material also endows it with the function of slow drug release. In recent years, hollow silica particle materials have attracted people's attention. Hollow silica particle materials not only...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K47/04A61K47/36
CPCA61K39/39A61K47/02A61K47/36A61K2039/55505
Inventor 容敏智金静维章明秋
Owner SUN YAT SEN UNIV
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