Oscillatory flow active control based liquid droplet preparation method and device

Abstract

The invention provides an oscillatory flow active control based liquid droplet preparation method. The method comprises the steps of firstly, preparing spacing first dispersed-phase liquid droplets, then, synchronously preparing spacing second dispersed-phase liquid droplets, and finally, subjecting the first dispersed-phase liquid droplets and the second dispersed-phase liquid droplets to arranged outputting through output pipes of different lengths. The invention further discloses an oscillatory flow active control based liquid droplet preparation device. The device comprises M T-shaped passages and a negative flow resistance oscillator, wherein the negative flow resistance oscillator is used for oscillating continuous-phase liquid into sine wave similar flow, a first liquid inlet pipe of each T-shaped passage serves as an inflow passage of first dispersed-phase liquid, and a second liquid inlet pipe of the corresponding T-shaped passage serves as an inflow passage of continuous-phase liquid; and liquid outlet pipes of the M T-shaped passages are jointly connected with an output pipeline. According to the method and the device, the reliability of preparation of high-viscosity liquid droplets is improved, operating steps of generating frequency and volume during liquid droplet preparation are simplified, and meanwhile, multiple liquid droplets of different properties can be synchronously generated.

Description

technical field [0001] The invention belongs to the field of microfluidic devices, in particular to a droplet preparation method and device based on active control of oscillating flow. Background technique [0002] The droplet generation methods can be mainly divided into two categories: passive and active. The passive micro-droplet preparation technology involves many variables. The volume and frequency of micro-droplet formation are not only related to the flow rate of the fluid and the size of the channel structure, but also It is related to the properties of the fluid (viscosity, interfacial tension), external environment and other parameters. Therefore, controlling the volume and frequency of droplets through passive droplet preparation requires a complex debugging process, which also leads to the difficulty of micro-droplet preparation. Flexibility is greatly reduced. Although the active droplet preparation technology can solve the technical problems of poor volume an...

AI Technical Summary

Problems solved by technology

[0002] The droplet generation methods can be mainly divided into two categories: passive and active. The passive micro-droplet preparation technology involves many variables. The volume and frequency of micro-droplet formation are not only related to the flow rate of the fluid and the size of the channel structure, but also It is related to the properties of the fluid (viscosity, interfacial tension), external environment and other parameters. Therefore, controlling the volume and frequency of droplets through passive droplet preparation requires a complex debugging process, which also leads to the difficulty of micro-droplet preparation. Much less flexibility

Although the active droplet preparation technology can solve the technical problems of poor volume and frequency controllability in the traditional passive droplet preparation technology, the active droplet preparation technology requires additional equipment to interfere with the droplet formation.

Due to the existence of external equipment, the structure of the active micro-droplet chip is often more complex, which affects the reliability, and the volume is larger, the cost is higher, and the portability is poor.

In addition, the external field force applied in the active control often acts on the reagent, which is easy to have adverse effects or damage to the reagent and affect the experimental results.

Images