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Colon cancer cell detector with optimal parameters

A technology for colon cancer and cancer cells, which is applied in the fields of instruments, electrical digital data processing, special data processing applications, etc., can solve the problem of difficulty in searching for the optimal parameters for the classification of optimal feature subsets of gene microarray data, and avoid inefficiencies. As well as randomness, good de-correlation, and fast training

Inactive Publication Date: 2018-10-16
ZHEJIANG UNIV
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Problems solved by technology

[0003] In order to overcome the shortages that it is difficult to search for the optimal feature subset of gene microarray data and the best parameters for classification, the purpose of the present invention is to provide a colon cancer model with intelligent optimization of parameters

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  • Colon cancer cell detector with optimal parameters
  • Colon cancer cell detector with optimal parameters
  • Colon cancer cell detector with optimal parameters

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Embodiment Construction

[0050] The present invention will be described in detail below according to the accompanying drawings.

[0051] refer to figure 1 , a colon cancer cancer cell detector with optimal parameters, the system consists of a gene microarray read-in module 1, a data preprocessing and feature sorting module 2, a parameter optimization module 3, and a model output module 4; wherein:

[0052] Gene microarray read-in module 1, which reads in the category labels of all gene microarrays Y=[y 1 ,y 2 ,...,y m ], where y i =k,k∈(-1,1), and the gene microarray expression values ​​of all samples:

[0053]

[0054] where each line x i Represents the expression values ​​of all genes in a sample, corresponding to each column x j Represents the expression value of a gene in all samples, the subscript i indicates the i-th sample, a total of m, and the subscript j indicates the j-th gene, a total of n.

[0055] The data preprocessing and feature sorting module 2 is the process of normalizing a...

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Abstract

The invention discloses a colon cancer cell detector with optimal parameters. The system is composed of a gene microarray read-in module, a data preprocessing and feature ordering module, a parameteroptimization module and a model output module. According to the system, input gene microarray data is preprocessed firstly, then all remaining genes are subjected to importance ranking, and the correlation is calculated through fractional statistics; the contribution degree is calculated through a classifier criterion function, and the importance of all the genes is ranked. According to an improved optimizing method, adaptability detection and population disturbance are added under an original intelligent optimizing algorithm, population diversity loss can be avoided, and the optimizing process can be prevented from being trapped in local optimum. Then the sought optimal parameters are adopted as classifier parameters, model building is completed, and the result is output. The system has very good decorrelation, and is high in precision.

Description

technical field [0001] The invention relates to the technical field of application of gene microarray data, in particular to a colon cancer cancer cell detector with optimal parameters. Background technique [0002] Gene chip (gene chip) is currently the most complete and widely used chip in the biochip family, immobilizing many specific oligonucleotides or DNA fragments (called probes) in each pre-set area of ​​the chip , the sample to be tested is labeled and hybridized with the chip, using the principle of complementary base pairing for hybridization, by detecting the hybridization signal and performing computer analysis to detect the existence and amount of the corresponding fragment, which is used for gene function research and Genome research, clinical detection of diseases and many other aspects. The most successful typical gene chip is to arrange DNA in an orderly array on the surface of the medium, so it is also called DNA microarray (DNA microarray). According to...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/20G06N3/00
CPCG06N3/006G16B25/00
Inventor 刘兴高高信腾孙元萌
Owner ZHEJIANG UNIV
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