Liquid quantification device and application thereof

Abstract

The invention discloses a liquid quantification device. The liquid quantification device comprises a base body and a liquid quantification area arranged on the base body; the liquid quantification area has a predetermined volume, a liquid quantification inlet and a liquid quantification outlet are formed in the two ends of the liquid quantification area respectively, and liquid flows into the liquid quantification area from the liquid quantification inlet and reaches the liquid quantification outlet after the liquid quantification area is fully filled with the liquid; a liquid identification device is arranged at a corresponding position of the liquid quantification outlet and used for identifying the liquid which reaches the liquid quantification outlet. The invention also discloses application of the liquid quantification device in a microfluidic chip. By adopting the liquid quantification device, the accuracy of quantification and detection can be improved.

Description

technical field [0001] The invention relates to the field of fluid quantification, in particular to a liquid quantification device and its application. Background technique [0002] In Vitro Diagnosis (In Vitro Diagnosis, IVD) refers to taking out samples (blood, body fluids, tissues, etc.) from the human body for detection and analysis to diagnose diseases. The detection process requires corresponding instruments and reagents, which consist of in vitro diagnostic system. In vitro diagnostic systems are roughly divided into two types; one is represented by the testing center laboratory, which has system modularization, automation, and pipeline-style sample testing, so it also has high-throughput, high-efficiency, and high-sensitivity. Advantages, but the entire system also has the disadvantages of high cost, large volume, and professional operation. It is mainly used in large hospitals. The other one is represented by point-of-care testing (POCT). Its system is integrated,...

AI Technical Summary

Problems solved by technology

Existing microfluidic chips are mainly based on qualitative detection, and there are few microfluidic chips that can realize quantitative detection, and the structure is complex; especially the fluid quantitative devices involved, some of which use specific volume storage bags, Although this kind of quantitative structure is simple, the phenomenon of liquid hanging on the surface of the holding bag is very easy to occur (when the liquid is pressed out from the holding bag, part of the liquid hangs in the bag, and it is impossible to ensure that all the liquid is pressed out), and the holding bag is The amount of deformation is different for each squeeze, so the amount of liquid remaining in the holding bag is inconsistent each time, and the amount of liquid squeezed out is different, especially when a small amount of liquid is needed, the error of the holding bag is even greater , compared with microfluidic chips, what is needed is tens of microliters, so the quantitative accuracy of the storage bag cannot meet the requirements, and the quantitative accuracy is poor, which affects the detection results. At the same time, the storage bag needs to be built into the chip. Increased the difficulty of chip production

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