Key-protein recognition method based on fusion of biological and topological features

A technology of topological features and identification methods, applied in the field of biological information, can solve the problems of lack of key protein biological characteristics, low accuracy of key proteins, dependence on the accuracy of protein interaction networks, etc., to expand the scope of application and practicability, and improve efficiency. , the effect of improving the accuracy
CN108733976AActive Publication Date: 2018-11-02YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2018-11-02

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Abstract

The invention belongs to the field of bioinformatics technology, and particularly relates to a key-protein recognition method based on fusion of biological and topological features. The method includes: assigning a score, which indicates an importance degree of each protein vertex, to the protein vertex, wherein the scores of all the vertices constitute a vector of n columns; giving initial valuesof the scores, constituting the attribute values of the protein vertices according to biological information and values of topological characteristics, and constituting an attribute matrix; and finally, carrying out descending arrangement according to the scores, and outputting k proteins corresponding to the scores, namely final results. Combination of the topological characteristics of a protein interaction network and the protein biological-attributes facilitates identification of key proteins, and improves efficiency of key-protein recognition.
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Description

technical field

[0001] The invention belongs to the technical field of biological information, and mainly relates to a technology for identifying key proteins in a protein interaction network by fusing biological and topological features, in particular to a method for identifying key proteins in a PPI network based on network topology information and protein biological attributes. Background technique

[0002] In biological cells, key proteins are indispensable for the realization of cell functions, and have important application value for the survival of organisms, drug target design, disease treatment and prediction, etc. Therefore, the identification of key proteins has become one of the important research tasks in the field of proteomics. Although some achievements have been made in the identification of key proteins in protein interaction networks, due to the high complexity and randomness of living systems, effective methods in other fields often do not necessarily ach...

Claims

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