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NIPT (Non Invasive Prenatal Testing) Z value result correction method and device and computer readable storage medium

A calibration method and technology of a calibration device, which are applied in calculation, special data processing applications, instruments, etc., can solve problems such as low accuracy of NIPTZ value results, and achieve the effect of improving accuracy

Active Publication Date: 2018-11-02
成都凡迪医疗器械有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

Due to the differences of the three chromosomes (Chr13, Chr18, and Ch21) detected by NIPT, and the results obtained by different algorithms are not completely consistent, the final NIPT Z value results have a problem of low accuracy

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  • NIPT (Non Invasive Prenatal Testing) Z value result correction method and device and computer readable storage medium
  • NIPT (Non Invasive Prenatal Testing) Z value result correction method and device and computer readable storage medium

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Embodiment Construction

[0023] The existing NIPT Z value calculation algorithms usually include the conventional U test method, autosomal correction method and GC correction method, and the NIPT Z value results calculated by different methods may be different. In addition, due to the differences of the three chromosomes (Chr13, Chr18, and Ch21) detected by NIPT, it is difficult to obtain a final and more accurate judgment result for samples whose final NIPT Z value results are in the critical area.

[0024] In the embodiment of the present invention, according to the multiple NIPT Z value results of the detected chromosomes, the linear regression analysis operation is performed on them, and the linear function corresponding to the detected chromosomes is fitted, so that consistent NIPT Z value results can be obtained. The new Z value corresponding to the detected chromosome is determined according to the fitted linear function to determine the corrected NIPT Z value result corresponding to the detecte...

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Abstract

The invention relates to a NIPT (Non Invasive Prenatal Testing) Z value result correction method and device and a computer readable storage medium. The method comprises the steps of: respectively using a plurality of NIPT Z value results of a detected chromosome, which are obtained by calculation, as independent variables, and respectively carrying out a linear regression analysis operation on theindependent variables to obtain a linear regression coefficient corresponding to each NIPT Z value result; according to the linear regression coefficient corresponding to each NIPT Z value result, fitting out a linear function corresponding to the detected chromosome; and according to the linear function, determining a new Z value corresponding to the detected chromosome. According to the scheme,the consistent NIPT Z value results can be obtained, and accuracy of the NIPT Z value results can be improved.

Description

technical field [0001] The invention relates to the field of biological detection, in particular to a Z value result correction method and device of NIPT, and a computer-readable storage medium. Background technique [0002] Non-invasive prenatal testing (Non Invasive Prenatal Testing, NIPT) technology only needs to collect venous blood from pregnant women, use next-generation DNA sequencing technology to sequence the free DNA fragments in the peripheral plasma of pregnant women, and conduct bioinformatics analysis on the sequencing results, namely The genetic information of the fetus can be obtained from it, so as to detect whether the fetus has chromosomal diseases. [0003] The existing calculation algorithms of NIPT Z value usually include conventional U test method, autosomal correction method and GC correction method. Due to the differences of the three chromosomes (Chr13, Chr18, and Ch21) detected by NIPT, and the results obtained by different algorithms are not comp...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/24
Inventor 王正肖岳云霞钱雨飞
Owner 成都凡迪医疗器械有限公司