Quasi-moving bed separation

Abstract

A quasi-moving bed separator which can monitor a concentration distribution of components in a circulating fluid flow passage in real time or can automatically determine an optimum operating condition. The separator comprises a concentration detector provided in the circulating fluid flow passage and concentration measuring means provided in a take-out port leading from the circulating fluid flow passage.

Description

Technical field [0001] The invention relates to a simulated moving bed separation device, in particular to a simulated moving bed separation device capable of real-time detection of the entire concentration distribution formed in a simulated moving bed, and to a real-time grasp of the operating state of the simulated moving bed separation device without It is a simulated moving bed separation device that can produce defective products, reduce sample loss, obtain high recovery rate, and have high production efficiency, and can separate various components from a mixture containing several components. Real-time, more correctly, it is possible to grasp the change of the characteristic curve of the operating conditions with the concentration (or purity, depending on the occasion) of each sampling cycle according to each sampling cycle or each cycle of operation time or with each cycle of operation The characteristic curve of the concentration of time (according to the occasion, it ...

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Problems solved by technology

[0012] In the control method disclosed in this gazette, since the piping between the supply port and the discharge port and the concentration detector is generally relatively long, a time lag actually occurs for the concentration detection of the supply port or the discharge port, and the The concentration cannot be detected correctly

In addition to the time lag, component diffusion and convection will also occur in the extraction solution or extraction residue flowing through the piping, so from this point of view, there is also a problem that the concentration detection cannot be performed correctly.

[0013] This original simulated moving bed chromatographic separation technology has the problem that it is difficult to accurately grasp the concentration and optical purity that change with time, so that it cannot quickly judge the separation state

And because the separation state cannot be judged quickly, it is also difficult to set the operating conditions such as the time interval of the discontinuous movement of the inlet and the outlet, the flow rate of the circulating fluid, the temperature, etc., as optimal conditions. There is a problem that it is difficult to achieve high-efficiency chromatographic separation

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