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Glycyrrhizin arginine salt and preparation method and application thereof

A compound and name technology, applied in the field of arginine glycyrrhizin and its preparation and use, can solve the problems of low oral bioavailability, poor absorption, easy formation of molecular aggregates and the like

Inactive Publication Date: 2018-12-04
BEIJING HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, all oral preparations of glycyrrhizic acid or its salts have the problem of low oral bioavailability, because glycyrrhizic acid easily forms molecular aggregates when it meets water
The absorption in the gastrointestinal tract is poor, so it is urgent to develop oral or injectable formulations of glycyrrhizic acid with high bioavailability

Method used

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  • Glycyrrhizin arginine salt and preparation method and application thereof
  • Glycyrrhizin arginine salt and preparation method and application thereof
  • Glycyrrhizin arginine salt and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 Glycyrrhizin arginine salt

[0036] 8.2 g of glycyrrhizin and 1.7 g of arginine (1:1) were reacted in 100 ml of aqueous solution at room temperature for 24 hours, then frozen in a low-temperature refrigerator, and the frozen reactant was dried in a low-temperature desiccator. Obtain 9.9 g of dry arginine glycyrrhizin.

Embodiment 2

[0037] Embodiment 2 glycyrrhizin arginine salt

[0038] 8.2g of glycyrrhizin and 1.7g of arginine (1:1) were reacted in 100ml of aqueous solution at room temperature for 24 hours. Under the condition of vigorous stirring, 2L of acetone was slowly added, and a large amount of white crystalline powder was precipitated. Dry to obtain 8.1 g of white crystalline powder, yield 81.9%

Embodiment 3

[0039] Embodiment 3 glycyrrhizin arginine salt

[0040] 8.2 g of glycyrrhizin and 3.4 g of arginine (1:2) were reacted in 100 ml of aqueous solution at room temperature for 24 hours, then frozen in a low-temperature refrigerator, and the frozen reactant was dried in a low-temperature desiccator. Obtain dry arginine glycyrrhizin 11.6g.

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PUM

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Abstract

The invention discloses a production method of a novel compound glycyrrhizin arginine salt. The compound can be used for treating hepatitis, liver fibrosis and liver cirrhosis and improving the abnormal liver function.

Description

technical field [0001] The invention relates to a new medicinal composition which can be used for treating liver diseases, in particular to a salt formed by combining glycyrrhizin and arginine. Background technique [0002] According to the data released by the World Health Organization, more than 1 million people die of liver disease every year in the world. my country is a country with a large number of liver diseases, and the incidence and mortality of liver diseases rank first in the world. Liver cirrhosis and liver cancer will appear in the advanced stage of liver disease. The development of liver disease is a slow and gradual process, including degeneration and necrosis of liver cells → inflammatory cell infiltration → liver fibrosis, nodular regeneration of liver cells → repeated alternation → lobular structure, circulatory transformation → liver smallness, degeneration and hardening → liver cirrhosis . Early liver disease can be reversed, but once liver cirrhosis ...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/00A61K31/704A61P1/16A61P35/00
CPCC07H1/00C07H15/256C07J63/008
Inventor 林雅军张换胡刚魏洁郭君
Owner BEIJING HOSPITAL
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