Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug transport protein gene polymorphism site related to antituberculosis drug liver injury generation, and applications thereof

A transporter and gene locus technology, applied in the field of polymorphic loci of drug metabolism genes, can solve problems that affect patient prognosis, weaken patient treatment options, and liver failure

Active Publication Date: 2018-12-07
上海市预防医学研究院 +1
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the occurrence of drug-induced liver damage often leads to the weakening or even interruption of the treatment plan of some patients during chemotherapy for tuberculosis, seriously affecting the prognosis of patients, and the possibility of liver failure or even death due to acute liver injury

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug transport protein gene polymorphism site related to antituberculosis drug liver injury generation, and applications thereof
  • Drug transport protein gene polymorphism site related to antituberculosis drug liver injury generation, and applications thereof
  • Drug transport protein gene polymorphism site related to antituberculosis drug liver injury generation, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Embodiment 1 research object and method

[0143] 1Clinical case collection

[0144] Three designated hospitals for tuberculosis treatment were selected in Shanghai, and patients diagnosed for the first time and receiving anti-tuberculosis drug treatment were collected according to the predetermined inclusion and exclusion criteria. On the basis of informed consent, the included cases were given anti-tuberculosis treatment for 6 months After follow-up observation, a total of 139 newly treated cases with 6-month follow-up and complete clinical information were obtained. The collected clinical information includes age, weight, past medical history (including hepatitis A, hepatitis B, schistosomiasis, liver fibrosis, fatty liver, alcoholic cirrhosis and other related liver damage history), smoking and drinking history, allergy history, anti-tuberculosis drug treatment Protocols, clinical routine testing indicators, etc. This study was approved by the Ethical Review Commit...

Embodiment 2

[0197] This embodiment provides a kit for detecting the susceptibility to liver injury caused by anti-tuberculosis drugs.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a drug transport protein gene polymorphism site related to antituberculosis drug liver injury generation, and applications thereof, and more specifically relates to a gene polymorphism site with obvious correlation to antituberculosis drug liver toxicity. It is shown by experiment results that the SNP site related to antituberculosis drug liver injuries can be taken as a sensitive antituberculosis drug liver injury susceptibility biomarker, can be used for clinical evaluation that whether liver injury of a patient taking the antituberculosis drug is easily caused, and isused for guiding clinical medication.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular, the invention relates to the drug metabolism gene polymorphism site related to the occurrence of anti-tuberculosis drug-induced liver injury. Background technique [0002] Liver damage caused by taking prescription or over-the-counter drugs is becoming a growing medical and health concern worldwide. At least 1000 drugs have been reported to cause liver toxicity. Drug-induced liver injury is the most concerned issue of the Food and Drug Administration (FDA) during the drug development process, and is an important reason for the elimination of new drugs, drug recalls from the market, and increased clinical monitoring during drug use. However, it is difficult to detect drug hepatotoxicity in preclinical studies relying on animal experiments, and based on the scale of general clinical research, it is often difficult to detect drug hepatotoxicity, usually only after large-scale population us...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 帅怡周彤肖萍王彦琴霍倩娄丹吴凡仲伟鉴沈鑫吴哲渊
Owner 上海市预防医学研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com