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Method for preparing carbocisteine

A technology of carbocisteine ​​and system, applied in the field of preparation of carbocisteine, can solve the problems of small carbocisteine ​​crystals and the like

Active Publication Date: 2018-12-21
SHANXI YUNPENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the deficiencies in the prior art, the invention provides a method for preparing carbocisteine, which solves the problems that the carbocisteine ​​crystals produced by the existing carbocisteine ​​crystallization process are small, etc.

Method used

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  • Method for preparing carbocisteine
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  • Method for preparing carbocisteine

Examples

Experimental program
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Embodiment 1

[0023] A preparation method of carbocisteine, comprising the following steps:

[0024] S1. Put L-cysteine ​​and 60kg of chloroacetic acid in purified water for condensation reaction, control the temperature of the system below 50°C, and add liquid ammonia to adjust the pH of the system to 7.0-7.5;

[0025] S2. Adjust the temperature of the system to 60°C, add hydrochloric acid to adjust the pH of the system to 6, and add activated carbon to decolorize;

[0026] S3, filter, adjust the temperature of the filtrate to 45-55°C, add hydrochloric acid with a molar mass 0.9 times the molar mass of L-cysteine ​​to the filtrate at one time, and let stand;

[0027] S4. After 1 hour, measure the pH of the filtrate, add dropwise hydrochloric acid to adjust the pH, stir for 1 min, let stand for 10 min, measure the pH of the filtrate until the pH of the filtrate is 2.8;

[0028] S5. Adjust the temperature of the system to be below 20°C, centrifuge, and wash the precipitate with purified wat...

Embodiment 2

[0030] A preparation method of carbocisteine, comprising the following steps:

[0031] S1. Put 100kg of L-cysteine ​​and chloroacetic acid in purified water for condensation reaction, control the temperature of the system below 50°C, and add liquid ammonia to adjust the pH of the system to 7.0-7.5;

[0032] S2. Adjust the temperature of the system to 60°C, add hydrochloric acid to adjust the pH of the system to 6, and add activated carbon to decolorize;

[0033] S3, filter, adjust the temperature of the filtrate to be 45-55 ° C, add 69 kg of hydrochloric acid with a mass concentration of 30% to the filtrate at one time, and let it stand;

[0034] S4. After 1 hour, measure the pH of the filtrate, add dropwise hydrochloric acid to adjust the pH, stir for 1 min, let stand for 10 min, measure the pH of the filtrate until the pH of the filtrate is 2.8;

[0035] S5. Adjust the temperature of the system to be below 20°C, centrifuge, and wash the precipitate with purified water until...

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Abstract

The invention relates to the field of medicine preparation and particularly relates to a method for preparing carbocisteine. The method comprises the following steps: on the basis of the prior art, preparing a carbocisteine crystal; at a fine stirring stopping state, pouring hydrochloric acid into a reaction liquid at one time according to a calculation amount, leaving to stand, and carrying out carbocisteine crystallization in a point dynamic stirring mode. By adopting the method, the problem that a crystal cannot grow large as a great number of crystal nucleuses are formed in a stirring state can be effectively avoided, a large crystal can be prepared, the crystal is up to 100-500mu m when being observed microscopically, the washing water amount is reduced by 70%, and the content is increased to 99.5% or greater from 99%.

Description

technical field [0001] The invention relates to the field of pharmacy, and more specifically, relates to a preparation method of carbocisteine. Background technique [0002] The raw material of carbocisteine ​​is an amino acid drug, which mainly affects the secretion of bronchial glands at the cellular level. It can break the disulfide bond of mucin in mucus, increase the secretion of low-viscosity sialomucin, and increase the secretion of high-viscosity fucoidin. The production of protein is reduced, so that the viscosity of sputum is reduced, which is conducive to the discharge of sputum. The raw materials are amino acid drugs. Its molecular structure contains carboxyl and amino groups at the same time, so it can be dissolved in dilute acid and dilute alkali. It is an amphoteric compound, and its isoelectric point is PH=2.8. [0003] Carbocisteine ​​completes the condensation reaction in a solution of PH=8 to obtain the target product, and then adds hydrochloric acid to ...

Claims

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Application Information

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IPC IPC(8): C07C319/14C07C319/28C07C323/58
CPCC07C319/14C07C319/28C07C323/58
Inventor 文献江
Owner SHANXI YUNPENG PHARMA