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Plasma miRNA marker related to assistant diagnoses of pancreatic cancer and application thereof

A technology for auxiliary diagnosis and pancreatic cancer, which is applied in the fields of genetic engineering and oncology, can solve the problems of incompletely consistent and insufficient research results, research on the diagnostic value of circulating miRNA, etc., and achieve high sensitivity and specificity, easy access and stability good sex effect

Active Publication Date: 2018-12-21
朱伟
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AI Technical Summary

Problems solved by technology

At present, there are insufficient studies on the diagnostic value of circulating miRNAs in pancreatic cancer, and due to differences in research methods and included populations, the results of various studies are not completely consistent.

Method used

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  • Plasma miRNA marker related to assistant diagnoses of pancreatic cancer and application thereof
  • Plasma miRNA marker related to assistant diagnoses of pancreatic cancer and application thereof
  • Plasma miRNA marker related to assistant diagnoses of pancreatic cancer and application thereof

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Experimental program
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Embodiment Construction

[0040] From 2010 to 2014, the inventor collected a large number of venous serum samples from patients with pancreatic cancer and normal physical examination people from the First Affiliated Hospital of Nanjing Medical University, and selected 159 cases of pancreatic cancer and 137 cases of normal people by sorting out the sample data. The control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 44 pairs of pancreatic cancer and adjacent tissues were retained. The selected patients' serum samples were all from patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were confirmed to be pancreatic cancer by pathology. The demographic data and clinical data of these samples were collected systematically.

[0041] Refer to the flowchart ( figure 1 ), randomly selected 20 pancreatic cancer samples and 10 normal controls from serum sam...

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Abstract

The invention discloses a plasma miRNA marker related to assistant diagnoses of pancreatic cancer and application thereof. The marker is one or more of let-7b-5p, miR-192-5p, miR-19a-3p, miR-19b-3p, miR-223-3p, and miR-25-3p. Plasma miRNA as a new biomarker has the characteristics of good stability, high sensitivity and specificity, and is minimally invasive and can be easily obtained. The development and utilization of such molecular markers can provide a new direction for the diagnosis and further treatment of various diseases comprising tumors. The research will be more targeted to obtain apancreatic cancer serum miRNA marker with clinical diagnostic potentials. The research confirms the reliability and reproducibility of this group of miRNAs as a non-invasive marker for the diagnosisof pancreatic cancer.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a serum miRNA marker related to auxiliary diagnosis of pancreatic cancer and its application. Background technique [0002] Pancreatic cancer (Pancreatic cancer, PC) is a highly malignant and lethal digestive tract malignancy, and its morbidity and mortality have increased significantly in recent years. Pancreatic cancer is difficult to diagnose and treat compared to other malignancies. At present, surgical treatment is still the most effective way to treat pancreatic cancer, but most patients have no symptoms in the early stage of the disease, and are already in the middle and late stages when they see a doctor, making the 5-year survival rate less than 10%. At present, the research on the molecular and clinical characteristics of pancreatic cancer continues to deepen, and clinical screening and treatment methods have also made great progress. However, these metho...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113C12N15/11
CPCC12Q1/6886C12Q2600/178C12Q2600/158
Inventor 苗毅朱伟卫积书周鑫黄泽波陆子鹏邹璇
Owner 朱伟
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