Compound low-concentration atropine eye drops and preparation method thereof

A technology of atropine and eye drops, applied in drug combination, drug delivery, medical formula, etc., can solve the problems of inconspicuous and slow effect of myopia treatment, and achieve the effect of preventing and treating myopia

Active Publication Date: 2018-12-28
上海阿尔福斯医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although health care therapy has no side effects on the human body, the treatment effect on myopia is relatively slow or not obvious, and it needs to be used fo

Method used

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  • Compound low-concentration atropine eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Wash 50g of medlar and 25g of mint with distilled water, then put them into a decoction machine, add 300ml of water for injection equivalent to 4 times the mass of the solid, decoct with low heat for 0.5 hours, filter after cooling and add 5g of pearl liquid, accurately Measure this mixed solution volume and be 295ml; In the filtrate, add atropine sulfate 0.001% (w / v), lutein 0.001% (w / v), taurine 0.001% successively based on the content in eye drops (w / v), vitamin A 0.001% (w / v), vitamin B10.001% (w / v), vitamin B6 0.001% (w / v), vitamin B12 0.001% (w / v), vitamin E 0.001 % (w / v), borneol 0.001% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (four parts)" eye drops, adding sodium dihydrogen phosphate, adjusting the pH to 7.2, Add sodium chloride, adjust the osmotic pressure to 302mOsm / L, add sodium hyaluronate, adjust the viscosity to 8mps, mix evenly, filter through a 0.22μm microporous membrane, steriliz...

Embodiment 2

[0056]Wash 3000g of medlar and 100g of mint with distilled water, put them into a decoction machine, add 62000ml of water for injection equivalent to 20 times the mass of the solid, decoct with slow fire for 0.5 hours, filter after cooling and add 1500g of pearl liquid, accurately Measure this mixed solution volume and be 63430ml; In the filtrate, add tropicamide 0.1% (w / v), lutein 0.01% (w / v), taurine successively based on the content in the eye drops 0.1% (w / v), vitamin A 0.01% (w / v), vitamin B10.1% (w / v), vitamin B6 0.1% (w / v), vitamin B12 0.1% (w / v), vitamin E 0.1% (w / v), borneol 0.1% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (fourth)" eye drops, add borax, adjust the pH to 7.3, add Sodium chloride, adjust the osmotic pressure to 306mOsm / L, add methylcellulose, adjust the viscosity to 7mps, mix evenly, filter through a 0.22μm microporous membrane, sterilize, single-dose aseptic subpackaging, and pass t...

Embodiment 3

[0058] Wash 500g of medlar and 200g of mint with distilled water, then put them into a decoction machine, add 7000ml of water for injection equivalent to 10 times the mass of the solid, decoct with a slow fire for 3 hours, filter after cooling and add 100g of pearl liquid, accurately Measure this mixed solution volume and be 7030ml; In the filtrate, add atropine sulfate 1% (w / v), lutein 0.01% (w / v), taurine 1% successively based on the content in eye drops (w / v), Vitamin A 0.01% (w / v), Vitamin B1 1% (w / v), Vitamin B6 1% (w / v), Vitamin B12 1% (w / v), Vitamin E 1% (w / v), borneol 1% (w / v), fully stirred, mixed evenly, according to the relevant requirements of "Chinese Pharmacopoeia 2015 Edition (fourth)" eye drops, add sodium dihydrogen phosphate, adjust the pH to 7.4, add Sodium chloride, adjust the osmotic pressure to 302mOsm / L, add sodium hyaluronate, adjust the viscosity to 8mps, mix evenly, filter through a 0.22μm microporous membrane, sterilize, single-dose aseptic subpackag...

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Abstract

The invention discloses compound low-concentration atropine eye drops and a preparation method thereof. The eye drops are mainly prepared from low-concentration atropine, lutein or a lutein derivative, fructus lycii, taurine, liquid pearl and multiple vitamins (A, B1, B6, B12 and E) by processing in a certain ratio. Drugs used in the compound eye drops conform to Chinese pharmacopoeia and United States Pharmacopeia, by means of functional collaborative treatment synergy of various natural drug active factors and atropine for vision, dose of atropine is reduced effectively, side effects on human eyes are reduced, ciliary muscle spasm can be eliminated, eyeball nutrition can be improved, asthenopia can be relieved, the eye drops have effects of improving eyesight and clearing away heat and toxic materials and have the capacity of enhancing human eye immunity and resisting eye diseases, the effect of preventing and treating myopia of adolescents and children is enhanced effectively, and the eye drops are high in safety, long in shelf life and good in biocompatibility with eye environment and has positive promotion and application values.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medication of pharmaceutical preparations, and in particular relates to a compound low-concentration atropine drug eye drop and a preparation method thereof. Background technique [0002] As various electronic devices such as computers, mobile phones, and electronic game consoles enter society and families, these electronic devices have brought great convenience to people's work and study, but have also caused some impact on people's eyesight. Due to the long-term use of these electronic devices, the eyes are overused, and the vision continues to weaken after a long period of overloaded work. The main symptoms are: blurred vision, dry eyes, hyperemia, and photophobia, usually accompanied by systemic symptoms, such as Difficulty concentrating, listlessness, memory loss, insomnia, emotional irritability, etc., have greatly affected people's life and health. [0003] In recent years, due to the c...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P27/10A61K9/08A61K47/46A61K47/10A61K47/22A61K47/20A61K31/46A61K31/4409A61K31/216A61K31/045A61K31/047A61K31/07A61K31/185A61K31/355A61K31/4415A61K31/51A61K31/714A61K35/618A61K36/534A61K36/815
CPCA61K9/0048A61K9/08A61K31/045A61K31/047A61K31/07A61K31/185A61K31/216A61K31/355A61K31/4409A61K31/4415A61K31/46A61K31/51A61K31/714A61K35/618A61K36/534A61K36/815A61K45/06A61K47/10A61K47/20A61K47/22A61K47/46A61P27/10A61K2300/00
Inventor 李大伟穆丹华周光大林建华张虹
Owner 上海阿尔福斯医药科技有限公司
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