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Pullulan empty hard capsule and preparation method thereof

A technology of pullulan polysaccharide and hollow hard capsules, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. Time stability, shortening disintegration time, and ensuring the effect of component content

Inactive Publication Date: 2019-01-04
JIANGSU LEFAN CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Above this pH range, the viscosity of the glue drops rapidly with the increase of the glue storage time, and the property of the glue is unstable, which has a great influence on dipping capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 40kg of 85°C purified water to the sol bucket, and take another 8kg of purified water to dissolve 192g of carrageenan, 144g of potassium chloride, 3.2g of sodium lauryl sulfate, and 5.25g of glycerin, and pour it into the sol bucket, and stir until the carrageenan After the gel was dissolved, 12 kg of pullulan with a pH value of 6.72 was slowly added while stirring. Then the glue solution was kept at 85°C for about 4 hours, stirred once an hour, and then lowered to 55°C for heat preservation and defoaming for later use.

[0022] On the production line, use the traditional dipping method to make capsules, and dry them at 25-40°C to obtain transparent hollow capsules with a water content of 12.1%, and the disintegration time is 7 minutes.

Embodiment 2

[0024] Add 40kg of purified water at 80°C to the sol bucket, and take another 8kg of purified water to dissolve 192g of carrageenan, 144g of potassium chloride, 3g of sodium lauryl sulfate, and 4.25g of glycerin, and pour them into the sol bucket. Stir After the carrageenan is dissolved, slowly add 12 kg of pullulan with a pH value of 6.63 while stirring. Then the glue solution was kept at 85°C for about 4 hours, stirred once an hour, and then lowered to 55°C for heat preservation and defoaming for later use.

[0025] On the production line, use the traditional dipping method to make capsules, and dry them at 25-40°C to obtain transparent hollow capsules with a water content of 12.0%, and the disintegration time is 7 minutes.

Embodiment 3

[0027] Add 40kg of 88°C purified water into the sol bucket, and take another 8kg of purified water to dissolve 192g of carrageenan, 144g of potassium chloride, 2.3g of sodium lauryl sulfate, and 4.25g of glycerin, and pour them into the sol bucket. After stirring until the carrageenan is dissolved, slowly add 12 kg of pullulan with a pH value of 6.35 while stirring. Then the glue solution was kept at 85°C for about 4 hours, stirred once an hour, and then lowered to 55°C for heat preservation and defoaming for later use.

[0028] On the production line, use the traditional dipping method to make capsules, and dry them at 25-40°C to obtain transparent hollow capsules with a water content of 12.0%, and the disintegration time is 7 minutes.

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PUM

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Abstract

The invention discloses a pullulan empty hard capsule and a preparation method thereof. The empty hard capsule comprises the following components in percentage by weight: 82-89% of pullulan having thepH value of 6-7, 1-1.4% of gel, 0.8-1.4% of a coagulant aid, 0.01-0.04% of a wetting agent, 0.01-0.04% of a surfactant and 10-14% of purified water. The preparation method comprises the following steps: weighing the various components; dissolving the gel, the coagulant aid, the wetting agent, the surfactant, an opacifying agent and food coloring with purified water at the temperature of 80-90 DEGC, transferring into an adhesive dissolving tank, stirring until the gel is dissolved, adding the pullulan having the pH value of 6-7 while stirring, cooling after the pullulan is completely dissolved, dipping the capsule by using a dipping glue method, and drying, thereby obtaining the product. According to the hard capsule disclosed by the invention, usage of the gel is reduced, the component content stability is ensured, and the disintegration time is shortened.

Description

technical field [0001] The invention relates to the technical field of hollow capsules, in particular to a pullulan hollow hard capsule and a preparation method thereof. Background technique [0002] Hollow capsule is an egg-shaped hollow shell that is refined from specific main materials and auxiliary materials and can be used to hold solid, semi-solid and liquid. Traditional hollow capsules use gelatin as the main material. This kind of hollow capsules has better disintegration performance and faster drug release, but there are many problems. Gelatin is made by hydrolyzing the skin and bones of animals such as pigs and cattle. The main component is collagen, which is easy to breed various microorganisms. It is a high-protein and high-fat substance, which is not conducive to the healthy diet of patients. At the same time, there may be animal Safety problems caused by disease transmission (such as mad cow disease, foot-and-mouth disease, bird flu, etc.). In addition, gelat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
CPCA61K9/4816A61J3/077A61K9/4883A61K47/02A61K47/10A61K47/20A61K47/36
Inventor 张轶弛潘婕方忠明刘培勇
Owner JIANGSU LEFAN CAPSULE
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