A preparation method for targeted release hollow capsules in intestinal tract

A hollow capsule and targeted technology, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of no anti-solvent effect, cumbersome preparation process of hollow capsules, and low acceptance, and achieve beautiful structure , various indicators and the effect of excellent safety and high acceptance

Active Publication Date: 2022-04-08
玖洲胶囊生物制药(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vegetable enteric-coated capsules are resistant to gastric acid, but have no anti-dissolution effect on the mixed digestive juice in the intestine
Therefore, enteric-coated capsules will dissolve in the intestinal tract, while gastric-soluble capsules are not acid-resistant, so they will dissolve in the stomach. Therefore, we propose a hollow capsule for targeted release in the intestinal tract, and the preparation process of the hollow capsule is cumbersome, and the acceptance lower

Method used

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  • A preparation method for targeted release hollow capsules in intestinal tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0033] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0034] S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0035] S3: Add raw material hypromellose and auxiliary material carrageenan and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add th...

Embodiment 2

[0045] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0046] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0047] S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0048] S3: Add raw material hypromellose and auxiliary material carrageenan and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add ...

Embodiment 3

[0058] In this example, a method for preparing hollow capsules for targeted release in the intestinal tract is proposed, which includes the following steps:

[0059] S1: Throwing tailings: according to the batch production instructions, after adding the measured purified water into the sol tank, turn on the stirring motor, then slowly add the weighed tailings into the sol tank, after stirring continuously, start to heat up;

[0060] S2: Heating up: Set the temperature controller at the desired temperature of 95°C, open the main steam valve, set the steam temperature to rise, open the steam electric control valve, steam enters through the upper interlayer pipe of the sol tank, flows out through the lower interlayer pipe, and then passes through After the output valve, it becomes condensed water and is discharged;

[0061] S3: Add raw material hypromellose and auxiliary material carrageenan and stir: when the temperature of the glue in the sol tank is heated to 95°C, slowly add ...

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Abstract

The invention discloses a method for preparing hollow capsules for targeted release in the intestinal tract, comprising the following steps: S1 feeding tailings: according to the requirements of batch production instructions, after adding measured purified water into the sol tank, turn on the stirring motor, and then Slowly add the weighed tailings into the sol tank, stir continuously, and start to heat up; S2 temperature rise: set the temperature controller at the required temperature of 95°C, open the main steam valve, set the steam temperature, and steam electric control The valve is opened, the steam enters through the upper interlayer pipe of the sol tank, then flows out through the lower interlayer pipe, and then becomes condensed water to be discharged after passing through the output valve; S3 is put into the raw material hypromellose and auxiliary material carrageenan and stirred; S4 is stirred at high temperature and vacuumed; S5 Cooling and stirring; S6 constant temperature stirring; S7 viscosity measurement-correction-gluing; S8 heat preservation; S9 enteric coating preparation; The needs of people with dietary habits are highly acceptable.

Description

technical field [0001] The invention relates to the technical field of hollow capsules, in particular to a preparation method for targeted release of hollow capsules in the intestinal tract. Background technique [0002] With the increase of capsule varieties, the diversity of its contents has gradually made people realize that there are compatibility problems between gelatin hollow capsules and some contents with special properties. For example, content containing aldehyde groups or reacting to form aldehyde groups under certain conditions may lead to cross-linking reaction of gelatin; content with strong reducibility may undergo Maillard reaction with gelatin; content with strong hygroscopicity It will cause the gelatin capsule shell to lose water and lose its original toughness. The above-mentioned stability problems of gelatin hollow capsules have drawn more attention to the development of new capsule materials. [0003] Therefore, with the development and industrializ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23P10/30A23L29/30A61K9/48A61K47/38
CPCA23P10/30A23L29/30A61K9/4816A61K9/4891A23V2002/00A23V2250/51086A23V2250/5036A23V2250/082A23V2250/086
Inventor 王有平
Owner 玖洲胶囊生物制药(广州)有限公司
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